{"doi":"10.1002/cnr2.1708","title":"Evaluating antitumor activity of <scp><i>Escherichia coli</i></scp> purine nucleoside phosphorylase against head and neck patient‐derived xenografts","abstract":"BACKGROUND: Purine nucleoside phosphorylase (PNP) gene transfer represents a promising approach to treatment of head and neck malignancies. We tested recombinant adenovirus already in phase I/II clinical testing and leading-edge patient-derived xenografts (PDX) as a means to optimize this therapeutic strategy. METHODS: Our experiments investigated purine base cytotoxicity, PNP enzyme activity following treatment of malignant tissue, tumor mass regression, viral receptor studies, and transduction by tropism-modified adenovirus. RESULTS: Replication deficient vector efficiently transduced PDX cells and mediated significant anticancer effect following treatment with fludarabine phosphate in vivo. Either 6-methylpurine or 2-fluoroadenine (toxic molecules generated by the PNP approach) ablated head and neck cancer cell proliferation. High levels of adenovirus-3 specific receptors were detected in human tumor models, and vector was evaluated that utilizes this pathway. CONCLUSIONS: Our studies provide the scientific foundation necessary to improve PNP prodrug cleavage and advance a new treatment for head and neck cancer.","journal":"Cancer Reports","year":2022,"id":287765,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9649,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":967782,"name":"Annette Ehrhardt","orcid":"0000-0002-6507-9026","position":1,"is_corresponding":false},{"id":249677,"name":"Bhagelu R. Achyut","orcid":"0000-0001-5670-6983","position":2,"is_corresponding":false},{"id":385201,"name":"Disha Joshi","orcid":"0009-0006-3840-4993","position":3,"is_corresponding":false},{"id":254874,"name":"Melissa Gilbert‐Ross","orcid":"0000-0002-1960-8302","position":4,"is_corresponding":false},{"id":370050,"name":"Chunzi Huang","orcid":null,"position":5,"is_corresponding":false},{"id":218085,"name":"Katharine Floyd","orcid":"0000-0002-0866-6961","position":6,"is_corresponding":false},{"id":502670,"name":"Anton V. Borovjagin","orcid":"0000-0001-7758-1462","position":7,"is_corresponding":false},{"id":385199,"name":"William B. Parker","orcid":"0000-0002-7387-939X","position":8,"is_corresponding":false},{"id":232936,"name":"Eric J. Sorscher","orcid":"0000-0001-9341-3354","position":9,"is_corresponding":false},{"id":385200,"name":"Jeong S. Hong","orcid":"0000-0003-4719-1855","position":10,"is_corresponding":false},{"id":385203,"name":"Regina Rab","orcid":"0000-0003-0293-4694","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:30:01.051685Z","pmid":"36253876","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}