{"doi":"10.1002/cncr.70197","title":"Effects of physical activity on performance measures in older adult cancer survivors","abstract":"BACKGROUND: Older adults who are long-term survivors of cancer are vulnerable to developing mobility disability than noncancer controls; it is unknown if physical activity improves objective measures of lower-extremity physical performance, such as the Short Physical Performance Battery (SPPB) and 400-m walk, that are predictors of mobility disability in this population. METHODS: The Lifestyle Interventions and Independence for Elders (LIFE) study was a multicenter randomized trial that enrolled 1635 adults aged 70-89 years, of whom 371 (22.7%) reported a history of cancer and were included in this secondary analysis. Participants were randomized to health education or physical activity. End points included the SPPB and 400-m walk. RESULTS: Randomization to physical activity, compared with health education, improved the SPPB score at 6 months (0.45 points [95% confidence interval (CI), 0.05-0.86]; p = .027), 12 months (0.43 points [95% CI, 0.02-0.83]; p = .039), and 24 months (0.45 points [95% CI, 0.04-0.87]; p = .031). Randomization to physical activity, compared with health education, improved the 400-m walk speed at 6 months (0.042 m/s [95% CI, 0.017-0.066]; p < .001) and 12 months (0.036 m/s [95% CI, 0.011-0.060]; p = .004) but not 24 months (0.013 m/s [95% CI, -0.012 to 0.038]; p = .30). Moderate-to-vigorous intensity physical activity volume at 6 months mediated 25.3% (95% CI, 4.1-46.6 [p = .019]) and 30.3% [95% CI, 10.3-50.4 [p = .003]) of the effect of randomization on the SPPB score and 400-m walk speed at 12 months, respectively. CONCLUSION: Physical activity may improve lower-extremity physical performance compared to health education in older adults who are long-term survivors of cancer.","journal":"Cancer","year":2025,"id":537493,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9488,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1262192,"name":"Abigail L. Tice","orcid":"0000-0003-4351-3298","position":1,"is_corresponding":false},{"id":235345,"name":"Bret H. Goodpaster","orcid":"0000-0003-1275-5147","position":2,"is_corresponding":false},{"id":498524,"name":"Fanchao Yi","orcid":null,"position":3,"is_corresponding":false},{"id":274169,"name":"Shengping Yang","orcid":"0000-0001-6298-6301","position":4,"is_corresponding":false},{"id":821117,"name":"Mohamedtaki Abdulaziz Tejani","orcid":null,"position":5,"is_corresponding":false},{"id":273715,"name":"Justin C. Brown","orcid":"0000-0001-7540-4913","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-19T02:52:12.997494Z","pmid":"41370194","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}