{"doi":"10.1002/cncr.70138","title":"Understanding the role of neighborhood deprivation in racial disparities in triple‐negative breast cancer","abstract":"BACKGROUND: US Black women are twice as likely to be diagnosed with triple-negative breast cancer (TNBC), an aggressive subtype, as White women. Adverse neighborhood characteristics may contribute to the disparity. This study examined neighborhood deprivation in relation to TNBC, according to race and rurality. METHODS: The authors identified 40,095 non-Hispanic Black and White women diagnosed with invasive breast cancer in 2010-2017 in the Georgia Cancer Registry. The Neighborhood Deprivation Index (NDI), a composite measure, was calculated using 2011-2015 block group-level American Community Survey data. County-level rurality was measured via Georgia Department of Public Health data. We estimated multivariable odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between NDI, in quintiles, and each breast cancer subtype (TNBC, HER2-enriched, luminal B vs. luminal A breast cancer), overall, and according to race and rurality. RESULTS: Compared to least deprived neighborhoods, living in the most deprived neighborhoods was associated with a 33% (OR, 1.33; 95% CI, 1.19-1.48) increased odds of TNBC versus luminal A breast cancer. Race and rurality did not modify the association. However, estimates were less pronounced among non-Hispanic Black women (OR, 1.18; 95% CI, 1.00-1.39 vs. OR, 1.40; 95% CI, 1.18-1.65 among non-Hispanic White women) and women living in urban counties (OR, 1.33; 95% CI, 1.18-1.50 vs. OR, 1.52; 95% CI, 1.15-2.03 in rural counties). CONCLUSIONS: In this study, neighborhood deprivation was associated with increased odds of TNBC, regardless of race or rurality. Given Black women are more likely to live in deprived neighborhoods, neighborhood deprivation may contribute to racial disparities in TNBC occurrence.","journal":"Cancer","year":2025,"id":578884,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8798,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475797,"name":"Maret L. Maliniak","orcid":"0000-0002-0763-5231","position":1,"is_corresponding":false},{"id":475800,"name":"Jasmine M. Miller‐Kleinhenz","orcid":"0000-0002-8661-733X","position":2,"is_corresponding":false},{"id":292782,"name":"Leah Moubadder","orcid":"0000-0003-1048-8233","position":3,"is_corresponding":false},{"id":1488734,"name":"Demetria Smith‐Graziani","orcid":"0000-0001-9649-4049","position":4,"is_corresponding":false},{"id":305854,"name":"Jeffrey M. Switchenko","orcid":"0000-0002-5563-9325","position":5,"is_corresponding":false},{"id":435848,"name":"Kevin C. Ward","orcid":"0000-0001-5893-6192","position":6,"is_corresponding":false},{"id":475802,"name":"Lauren E. McCullough","orcid":"0000-0001-6723-9540","position":7,"is_corresponding":false},{"id":424322,"name":"Lauren E. Barber","orcid":"0000-0001-7321-6003","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:58:24.957414Z","pmid":"41128838","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}