{"doi":"10.1002/cncr.35901","title":"Survival outcomes of pulmonary metastasis‐directed local therapy in adenoid cystic carcinoma","abstract":"BACKGROUND: Adenoid cystic carcinoma (ACC) frequently has pulmonary metastasis (PM). Given limited systemic therapy options, these metastases are often treated with pulmonary metastasis-directed local therapy (PM-LT), although with unknown impact on overall survival (OS). This single institution, retrospective cohort study investigated the survival outcomes of PM-LT versus no PM-LT in ACC. METHODS: ACC patients with at least one PM (≥5 mm) were included. PM-LT was metastasectomy or radiotherapy. Clinicopathologic characteristics were compared between patients with and without PM-LT. Primary end point was OS from PM diagnosis, with landmark analysis at 6 months, 1 year, 2 years, and 3 years after metastasis diagnosis, with Cox proportional hazards model multivariate analysis and propensity score matching analysis. Subgroup analysis by ACC histology (solid/nonsolid) was performed. RESULTS: Of 219 included ACC, 119 (54%) had no PM-LT and 100 (46%) did. PM-LT patients had more nonsolid histology (p = .0008), oligometastases (p < .0001), exclusively PM (p = .02), and longer time to metastasis from diagnosis (p < .0001). On univariate analysis, PM-LT by 6 months, 1 year, and 2 years, but not by 3 years, increased OS. On multivariate analysis, PM-LT by 6 months (p = .12), 1 year (p = .08), or 3 years (p = .08) did not significantly increase OS, but PM-LT by 2-years had a borderline statistically significant association (p = .045). Of the 104 nonsolid ACC, 50 underwent PM-LT and 54 did not. On univariate and multivariate analysis, PM-LT did not increase OS at any time point for nonsolid ACC. CONCLUSION: This is the largest study of survival outcomes of PM-LT in metastatic ACC. Findings suggest PM-LT does not increase OS in unselected ACC.","journal":"Cancer","year":2025,"id":523382,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9263,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108396,"name":"Lei Feng","orcid":"0000-0002-4414-9910","position":1,"is_corresponding":false},{"id":1264205,"name":"Flavia Bonini","orcid":null,"position":2,"is_corresponding":false},{"id":767215,"name":"Luana Guimarães de Sousa","orcid":"0000-0002-3516-7105","position":3,"is_corresponding":false},{"id":1395805,"name":"Kaiwen Wang","orcid":"0000-0003-3857-4790","position":4,"is_corresponding":false},{"id":1396290,"name":"Juliana M. Siqueira","orcid":null,"position":5,"is_corresponding":false},{"id":236015,"name":"Quynh‐Nhu Nguyen","orcid":"0000-0001-5274-6291","position":6,"is_corresponding":false},{"id":14355,"name":"Adel K. El‐Naggar","orcid":"0000-0002-7175-9466","position":7,"is_corresponding":false},{"id":274147,"name":"Wayne L. Hofstetter","orcid":"0000-0002-4865-2783","position":8,"is_corresponding":false},{"id":247607,"name":"Boris Sepesi","orcid":"0000-0003-1442-611X","position":9,"is_corresponding":false},{"id":244404,"name":"Renata Ferrarotto","orcid":"0000-0002-3561-215X","position":10,"is_corresponding":false},{"id":1186969,"name":"Camilla O. Hoff","orcid":"0000-0002-4618-8438","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:50:03.004175Z","pmid":"40377125","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}