{"doi":"10.1002/cncr.35759","title":"Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505","abstract":"BACKGROUND: Chemotherapy is required to improve the overall survival (OS) of patients with resectable pancreatic ductal adenocarcinoma (PDAC). Assessing the impact of chemotherapy dose density (DD) on survival is difficult as a result of confounding. The objective of this study was to determine the impact of chemotherapy DD on OS in patients with resectable PDAC. METHODS: This was a secondary analysis of SWOG 1505, a randomized phase 2 trial of perioperative chemotherapy in resectable PDAC. DD was defined as the percentage of chemotherapy dose received of the total planned. Two landmark time points for OS were used: after surgery and at 40 weeks (which encompassed the entire treatment period). RESULTS: Of the 102 eligible patients enrolled, 73 (71%) underwent surgery, and median preoperative chemotherapy DD was 89%. Patients with ≥85% DD had higher OS compared to those with <85% DD (median, 38.1 vs. 17.2 months; p = .039). Of the 82 patients who survived to 40 weeks postrandomization, 67 underwent surgery, and median DD for all perioperative chemotherapy was 67%. In this cohort, DD ≥70% was associated with better OS (median, 32.2 vs. 14.0 months; p = .017). Perioperative DD was not significantly associated with pathologic response, margin status, or lymph node negativity. CONCLUSIONS: This is the first study to identify a prognostic association of chemotherapy DD with OS in patients undergoing perioperative chemotherapy and surgery for resectable PDAC. Patients who received ≥85% DD preoperatively and/or ≥70% DD perioperatively survived longer than those receiving a smaller proportion of protocol therapy.","journal":"Cancer","year":2025,"id":550158,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9333,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":823334,"name":"Sarah Colby","orcid":"0000-0002-2956-3072","position":1,"is_corresponding":false},{"id":226207,"name":"Davendra Sohal","orcid":"0000-0002-0182-8403","position":2,"is_corresponding":false},{"id":381432,"name":"Katherine A. Guthrie","orcid":"0000-0001-7257-8280","position":3,"is_corresponding":false},{"id":552336,"name":"Lisa A. Kachnic","orcid":"0000-0001-8239-9147","position":4,"is_corresponding":false},{"id":88001,"name":"E. Gabriela Chiorean","orcid":"0000-0003-3306-9592","position":5,"is_corresponding":false},{"id":250597,"name":"Andrew M. Lowy","orcid":"0000-0002-7106-0735","position":6,"is_corresponding":false},{"id":1445498,"name":"Flavio G. Rocha","orcid":"0000-0002-1656-5108","position":7,"is_corresponding":false},{"id":441217,"name":"Howard S. Höchster","orcid":"0000-0002-9893-1529","position":8,"is_corresponding":false},{"id":469426,"name":"Philip A. Philip","orcid":"0000-0002-6513-3491","position":9,"is_corresponding":false},{"id":395351,"name":"Syed A. Ahmad","orcid":"0000-0002-6179-5252","position":10,"is_corresponding":false},{"id":374743,"name":"Sameer H. Patel","orcid":"0000-0001-6442-1857","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T02:54:16.596730Z","pmid":"39932777","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}