{"doi":"10.1002/cncr.35650","title":"Patient‐reported persistent lymphedema and peripheral neuropathy among long‐term breast cancer survivors in the Carolina Breast Cancer Study","abstract":"BACKGROUND: Improved breast cancer treatment has lengthened survival but also has long-term impacts. Lymphedema and peripheral neuropathy are treatment-related sequelae that extend into survivorship. Co-occurrence of these conditions may further impair functional well-being. Few studies have estimated the burden of these conditions among diverse survivors. METHODS: Carolina Breast Cancer Study Phase 3 enrolled survivors diagnosed between 2008 and 2013 in North Carolina. Black and younger women (aged <50 years at diagnosis) were oversampled. With the use of ≥10 years of follow-up data, the prevalence of persistent lymphedema, peripheral neuropathy, and their co-occurrence was assessed. Prevalence differences (PDs) and 95% confidence intervals (CIs) were assessed according to patient and disease characteristics. RESULTS: A total of 1688 survivors were included, with an average of 11.1 years (SD, 0.6) postdiagnosis. The prevalence of persistent lymphedema, peripheral neuropathy, and their co-occurrence was 18.7%, 27.7%, and 8.8%, respectively. Lymphedema was higher among those receiving a mastectomy and with >5 lymph nodes removed, and peripheral neuropathy was higher among women treated with taxane-based chemotherapy. Co-occurrence was higher among women with >5 lymph nodes removed (vs. <5; PD, 5.4; 95% CI, 2.1 to 8.8) and those treated with taxane-based chemotherapy (vs. no chemotherapy; PD, 6.8; 95% CI, 3.9 to 9.7). The burden of lymphedema (PD, 2.7; 95% CI, 0.9 to 6.3) and peripheral neuropathy (PD, 5.8; 95% CI, 1.7 to 9.9) was higher among Black than White women. The prevalence of lymphedema (PD, 1.8; 95% CI, -1.5 to 5.1) and peripheral neuropathy (PD, 4.6; 95% CI, 0.8 to 8.4) was elevated among younger compared to older women. CONCLUSIONS: Lymphedema and peripheral neuropathy affect a substantial proportion of survivors. Interventions are needed to reduce this burden.","journal":"Cancer","year":2024,"id":477970,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8982,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":275144,"name":"Hazel B. Nichols","orcid":"0000-0003-0972-1560","position":1,"is_corresponding":false},{"id":190540,"name":"Qichen Wang","orcid":null,"position":2,"is_corresponding":false},{"id":921858,"name":"Rachel Hirschey","orcid":"0000-0001-8358-0650","position":3,"is_corresponding":false},{"id":340409,"name":"Erin E. Kent","orcid":"0000-0003-2503-2191","position":4,"is_corresponding":false},{"id":249118,"name":"Lisa A. Carey","orcid":"0000-0003-2388-4649","position":5,"is_corresponding":false},{"id":859182,"name":"Sandra C. Hayes","orcid":"0000-0002-7005-5184","position":6,"is_corresponding":false},{"id":743166,"name":"Adeyemi A. Ogunleye","orcid":"0000-0002-5098-180X","position":7,"is_corresponding":false},{"id":270126,"name":"Melissa A. Troester","orcid":"0000-0001-9506-6624","position":8,"is_corresponding":false},{"id":331730,"name":"Eboneé N. Butler","orcid":"0000-0002-4638-1190","position":9,"is_corresponding":false},{"id":741034,"name":"Rina Yarosh","orcid":"0000-0002-7411-3863","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39550629","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}