{"doi":"10.1002/cncr.35247","title":"The impact of cancer metastases on COVID‐19 outcomes: A COVID‐19 and Cancer Consortium registry‐based retrospective cohort study","abstract":"Abstract Background COVID‐19 can have a particularly detrimental effect on patients with cancer, but no studies to date have examined if the presence, or site, of metastatic cancer is related to COVID‐19 outcomes. Methods Using the COVID‐19 and Cancer Consortium (CCC19) registry, the authors identified 10,065 patients with COVID‐19 and cancer (2325 with and 7740 without metastasis at the time of COVID‐19 diagnosis). The primary ordinal outcome was COVID‐19 severity: not hospitalized, hospitalized but did not receive supplemental O 2 , hospitalized and received supplemental O 2 , admitted to an intensive care unit, received mechanical ventilation, or died from any cause. The authors used ordinal logistic regression models to compare COVID‐19 severity by presence and specific site of metastatic cancer. They used logistic regression models to assess 30‐day all‐cause mortality. Results Compared to patients without metastasis, patients with metastases have increased hospitalization rates (59% vs. 49%) and higher 30 day mortality (18% vs. 9%). Patients with metastasis to bone, lung, liver, lymph nodes, and brain have significantly higher COVID‐19 severity (adjusted odds ratios [ORs], 1.38, 1.59, 1.38, 1.00, and 2.21) compared to patients without metastases at those sites. Patients with metastasis to the lung have significantly higher odds of 30‐day mortality (adjusted OR, 1.53; 95% confidence interval, 1.17–2.00) when adjusting for COVID‐19 severity. Conclusions Patients with metastatic cancer, especially with metastasis to the brain, are more likely to have severe outcomes after COVID‐19 whereas patients with metastasis to the lung, compared to patients with cancer metastasis to other sites, have the highest 30‐day mortality after COVID‐19.","journal":"Cancer","year":2024,"id":467334,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.85,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":905028,"name":"Tianyi Sun","orcid":"0009-0005-2695-0885","position":1,"is_corresponding":false},{"id":374689,"name":"Deepak Ravindranathan","orcid":"0000-0003-0364-9027","position":2,"is_corresponding":false},{"id":282478,"name":"Clara Hwang","orcid":"0000-0002-0998-323X","position":3,"is_corresponding":false},{"id":637530,"name":"Nino Balanchivadze","orcid":null,"position":4,"is_corresponding":false},{"id":1299741,"name":"Sunny R. K. Singh","orcid":"0000-0003-3607-5605","position":5,"is_corresponding":false},{"id":105152,"name":"Elizabeth A. Griffiths","orcid":"0000-0002-0288-8248","position":6,"is_corresponding":false},{"id":258834,"name":"Igor Puzanov","orcid":"0000-0002-9803-3497","position":7,"is_corresponding":false},{"id":858885,"name":"Erika Ruíz‐García","orcid":"0000-0002-0446-123X","position":8,"is_corresponding":false},{"id":971090,"name":"Diana Vilar‐Compte","orcid":"0000-0001-8564-8735","position":9,"is_corresponding":false},{"id":1300095,"name":"Ana I. Cárdenas‐Delgado","orcid":null,"position":10,"is_corresponding":false},{"id":105165,"name":"Rana R. McKay","orcid":"0000-0002-0581-7963","position":11,"is_corresponding":false},{"id":859662,"name":"Taylor K. Nonato","orcid":null,"position":12,"is_corresponding":false},{"id":105195,"name":"Archana Ajmera","orcid":"0000-0002-4509-0447","position":13,"is_corresponding":false},{"id":827140,"name":"Peter Paul Yu","orcid":"0000-0003-0982-923X","position":14,"is_corresponding":false},{"id":1152356,"name":"Rajani Nadkarni","orcid":null,"position":15,"is_corresponding":false},{"id":1036800,"name":"Timothy E. O’Connor","orcid":"0000-0003-3249-807X","position":16,"is_corresponding":false},{"id":105203,"name":"Stephanie Berg","orcid":"0000-0001-6193-5350","position":17,"is_corresponding":false},{"id":1300096,"name":"Kim Ma","orcid":null,"position":18,"is_corresponding":false},{"id":105149,"name":"Dimitrios Farmakiotis","orcid":"0000-0001-8489-108X","position":19,"is_corresponding":false},{"id":905469,"name":"Kendra Vieira","orcid":null,"position":20,"is_corresponding":false},{"id":1260189,"name":"Panos Arvanitis","orcid":"0000-0002-0098-6071","position":21,"is_corresponding":false},{"id":971092,"name":"Renée Maria Saliby","orcid":"0000-0002-9241-597X","position":22,"is_corresponding":false},{"id":632011,"name":"Chris Labaki","orcid":"0000-0002-9584-8455","position":23,"is_corresponding":false},{"id":636671,"name":"Talal El Zarif","orcid":"0000-0002-4507-2396","position":24,"is_corresponding":false},{"id":231718,"name":"Trisha M. Wise‐Draper","orcid":"0000-0002-7279-4028","position":25,"is_corresponding":false},{"id":971091,"name":"Olga Zamulko","orcid":"0000-0001-5769-7425","position":26,"is_corresponding":false},{"id":1299742,"name":"Ningjing Li","orcid":"0000-0002-1170-7971","position":27,"is_corresponding":false},{"id":1152350,"name":"Brianne E Bodin","orcid":null,"position":28,"is_corresponding":false},{"id":482271,"name":"Melissa Accordino","orcid":"0000-0002-4156-7279","position":29,"is_corresponding":false},{"id":560392,"name":"Matthew Ingham","orcid":"0000-0002-5518-8413","position":30,"is_corresponding":false},{"id":366109,"name":"Monika Joshi","orcid":"0000-0003-4286-8492","position":31,"is_corresponding":false},{"id":971589,"name":"Hyma Polimera","orcid":null,"position":32,"is_corresponding":false},{"id":263558,"name":"Leslie A. Fecher","orcid":"0000-0002-6534-7457","position":33,"is_corresponding":false},{"id":263559,"name":"Christopher R. Friese","orcid":"0000-0002-2281-2056","position":34,"is_corresponding":false},{"id":1300097,"name":"James J. Yoon","orcid":null,"position":35,"is_corresponding":false},{"id":637531,"name":"Blanche H. Mavromatis","orcid":null,"position":36,"is_corresponding":false},{"id":374690,"name":"Jacqueline T. Brown","orcid":"0000-0002-1885-0906","position":37,"is_corresponding":false},{"id":1037381,"name":"Karen Russell","orcid":null,"position":38,"is_corresponding":false},{"id":637818,"name":"Rahul Nanchal","orcid":"0000-0001-7431-0763","position":39,"is_corresponding":false},{"id":376737,"name":"Harpreet Singh","orcid":"0000-0002-8001-4191","position":40,"is_corresponding":false},{"id":820717,"name":"Lisa Tachiki","orcid":"0000-0001-8057-8029","position":41,"is_corresponding":false},{"id":859661,"name":"Feras A. Moria","orcid":null,"position":42,"is_corresponding":false},{"id":618576,"name":"Gayathri Nagaraj","orcid":"0000-0002-7586-6920","position":43,"is_corresponding":false},{"id":1300098,"name":"Kimberly Cortez","orcid":null,"position":44,"is_corresponding":false},{"id":1300099,"name":"Saqib Hussen Abbasi","orcid":null,"position":45,"is_corresponding":false},{"id":105181,"name":"Elizabeth Wulff‐Burchfield","orcid":"0000-0003-1474-7095","position":46,"is_corresponding":false},{"id":263562,"name":"Matthew Puc","orcid":"0000-0002-9281-2262","position":47,"is_corresponding":false},{"id":105179,"name":"Lisa B. Weissmann","orcid":null,"position":48,"is_corresponding":false},{"id":1299743,"name":"Padmanabh Bhatt","orcid":"0000-0002-6814-0697","position":49,"is_corresponding":false},{"id":1300100,"name":"Melissa G. Mariano","orcid":null,"position":50,"is_corresponding":false},{"id":105187,"name":"Sanjay Mishra","orcid":"0000-0002-7775-9600","position":51,"is_corresponding":false},{"id":439554,"name":"Susan Halabi","orcid":"0000-0003-4135-2777","position":52,"is_corresponding":false},{"id":883071,"name":"Alicia Beeghly","orcid":null,"position":53,"is_corresponding":false},{"id":105190,"name":"Jeremy L. Warner","orcid":"0000-0002-2851-7242","position":54,"is_corresponding":false},{"id":299667,"name":"Benjamin French","orcid":"0000-0001-9265-5378","position":55,"is_corresponding":false},{"id":105141,"name":"Mehmet Asım Bilen","orcid":"0000-0003-4003-1103","position":56,"is_corresponding":false},{"id":481404,"name":"Cecilia A. Castellano","orcid":"0000-0002-3775-9737","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-19T02:05:10.907983Z","pmid":"38376917","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}