{"doi":"10.1002/cncr.34741","title":"Prognostic factors of childhood acute lymphoblastic leukemia with <i>TCF3::PBX1</i> in CCCG‐ALL‐2015: A multicenter study","abstract":"BACKGROUND: Contemporary risk-directed treatment has improved the outcome of patients with acute lymphoblastic leukemia (ALL) and TCF3::PBX1 fusion. In this study, the authors seek to identify prognostic factors that can be used to further improve outcome. METHODS: The authors studied 384 patients with this genotype treated on Chinese Children's Cancer Group ALL-2015 protocol between January 1, 2015 and December 31, 2019. All patients provisionally received intensified chemotherapy in the intermediate-risk arm without prophylactic cranial irradiation; those with high minimal residual disease (MRD) ≥1% at day 46 (end) of remission induction were candidates for hematopoietic cell transplantation. RESULTS: The overall 5-year event-free survival was 84.4% (95% confidence interval [CI], 80.6-88.3) and 5-year overall survival 88.9% (95% CI, 85.5-92.4). Independent factors associated with lower 5-year event-free survival were male sex (80.4%, [95% CI, 74.8-86.4] vs. 88.9%, [95% CI, 84.1-93.9] in female, p = .03) and positive day 46 MRD (≥0.01%) (62.1%, [95% CI, 44.2-87.4] vs. 87.1%, [95% CI, 83.4-90.9] in patients with negative MRD, p < .001). The presence of testicular leukemia at diagnosis (n = 10) was associated with particularly dismal 5-year event-free survival (33.3% [95% CI, 11.6-96.1] vs. 83.0% [95% CI, 77.5-88.9] in the other 192 male patients, p < .001) and was an independent risk factor (hazard ratio [HR], 5.7; [95% CI, 2.2-14.5], p < .001). CONCLUSIONS: These data suggest that the presence of positive MRD after intensive remission induction and testicular leukemia at diagnosis are indicators for new molecular therapeutics or immunotherapy in patients with TCF3::PBX1 ALL.","journal":"Cancer","year":2023,"id":349255,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":982030,"name":"Yang Wan","orcid":"0000-0002-5914-3327","position":1,"is_corresponding":false},{"id":1092427,"name":"Hongsheng Wang","orcid":"0000-0003-0079-0236","position":2,"is_corresponding":false},{"id":901930,"name":"Jiaoyang Cai","orcid":"0000-0003-2051-4044","position":3,"is_corresponding":false},{"id":982031,"name":"Jie Yu","orcid":"0000-0002-1103-2679","position":4,"is_corresponding":false},{"id":982032,"name":"Shaoyan Hu","orcid":"0000-0002-3386-6957","position":5,"is_corresponding":false},{"id":982033,"name":"Yongjun Fang","orcid":"0000-0002-1081-6471","position":6,"is_corresponding":false},{"id":982034,"name":"Ju Gao","orcid":"0009-0003-4765-4554","position":7,"is_corresponding":false},{"id":360959,"name":"Hua Jiang","orcid":"0000-0002-4552-0785","position":8,"is_corresponding":false},{"id":982035,"name":"Minghua Yang","orcid":"0000-0003-3746-1209","position":9,"is_corresponding":false},{"id":982513,"name":"Changda Liang","orcid":null,"position":10,"is_corresponding":false},{"id":982036,"name":"Runming Jin","orcid":"0000-0002-7233-0354","position":11,"is_corresponding":false},{"id":982037,"name":"Xin Tian","orcid":"0000-0001-9601-3751","position":12,"is_corresponding":false},{"id":982038,"name":"Xiuli Ju","orcid":"0000-0001-5464-3106","position":13,"is_corresponding":false},{"id":982039,"name":"Qun Hu","orcid":"0000-0002-1508-2796","position":14,"is_corresponding":false},{"id":982040,"name":"Hui Jiang","orcid":"0000-0001-7624-0607","position":15,"is_corresponding":false},{"id":1092428,"name":"Zhifan Li","orcid":"0000-0002-5836-1605","position":16,"is_corresponding":false},{"id":1092429,"name":"Ningling Wang","orcid":"0000-0001-5185-3968","position":17,"is_corresponding":false},{"id":982041,"name":"Lirong Sun","orcid":"0000-0003-1724-5146","position":18,"is_corresponding":false},{"id":982042,"name":"Alex Wing Kwan Leung","orcid":"0000-0001-9781-5908","position":19,"is_corresponding":false},{"id":982043,"name":"Xuedong Wu","orcid":"0009-0001-7612-1429","position":20,"is_corresponding":false},{"id":1034632,"name":"Xiaowen Qian","orcid":"0000-0002-0072-6632","position":21,"is_corresponding":false},{"id":301501,"name":"Maoxiang Qian","orcid":"0000-0003-2889-546X","position":22,"is_corresponding":false},{"id":262387,"name":"Chi Kong Li","orcid":"0000-0002-2810-5758","position":23,"is_corresponding":false},{"id":107683,"name":"Jun J. Yang","orcid":"0000-0002-0770-9659","position":24,"is_corresponding":false},{"id":901929,"name":"Jingyan Tang","orcid":"0000-0002-1905-5189","position":25,"is_corresponding":false},{"id":262725,"name":"Xiaofan Zhu","orcid":"0000-0002-2572-6495","position":26,"is_corresponding":false},{"id":901928,"name":"Shuhong Shen","orcid":"0000-0002-0001-642X","position":27,"is_corresponding":false},{"id":3069,"name":"Li Zhang","orcid":"0000-0002-3617-2627","position":28,"is_corresponding":false},{"id":254773,"name":"Ching‐Hon Pui","orcid":"0000-0003-0303-5658","position":29,"is_corresponding":false},{"id":982045,"name":"Xiaowen Zhai","orcid":"0000-0002-3505-0302","position":30,"is_corresponding":false},{"id":1092426,"name":"Honghong Zhang","orcid":"0000-0001-6232-8579","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:12:14.919810Z","pmid":"36943767","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}