{"doi":"10.1002/cncr.34676","title":"Influence of depression on breast cancer treatment and survival: A Kentucky population‐based study","abstract":"BACKGROUND: Depression is common among breast cancer patients and can affect concordance with guideline-recommended treatment plans. Yet, the impact of depression on cancer treatment and survival is understudied, particularly in relation to the timing of the depression diagnosis. METHODS: The Kentucky Cancer Registry data was used to identify female patients diagnosed with primary invasive breast cancer who were 20 years of age or older in 2007-2011. Patients were classified as having no depression, depression pre-cancer diagnosis only, depression post- cancer diagnosis only, or persistent depression. The impact of depression on receiving guideline-recommended treatment and survival was examined using multivariable logistic regression and Cox regression, respectively. RESULTS: Of 6054 eligible patients, 4.1%, 3.7%, and 6.2% patients had persistent depression, depression pre-diagnosis only, and depression post-diagnosis only, respectively. A total of 1770 (29.2%) patients did not receive guideline-recommended cancer treatment. Compared to patients with no depression, the odds of receiving guideline-recommended treatment were decreased in patients with depression pre-diagnosis only (odds ratio [OR], 0.75; 95% confidence interval [CI], 0.54-1.04) but not in patients with post-diagnosis only or persistent depression. Depression post-diagnosis only (hazard ratio, 1.51; 95% CI, 1.24-1.83) and depression pre-diagnosis only (hazard ratio, 1.26; 95% CI, 0.99-1.59) were associated with worse survival. No significant difference in survival was found between patients with persistent depression and patients with no depression (p > .05). CONCLUSIONS: Neglecting depression management after a breast cancer diagnosis may result in poorer cancer treatment concordance and worse survival. Early detection and consistent management of depression is critical in improving patient survival.","journal":"Cancer","year":2023,"id":325737,"datarank":0.9574660338396566,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.44236795316688465,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.44236795316688465,"corpus_percentile":78.88914674711843,"corpus_rank":2730,"citation_count":30,"citer_count":30,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5744,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":339332,"name":"Robin C. Vanderpool","orcid":"0000-0001-9995-4485","position":1,"is_corresponding":false},{"id":317116,"name":"Laurie E. McLouth","orcid":"0000-0002-4888-6520","position":2,"is_corresponding":false},{"id":1044626,"name":"Edward H. Romond","orcid":null,"position":3,"is_corresponding":false},{"id":302955,"name":"Quan Chen","orcid":"0000-0001-5570-2462","position":4,"is_corresponding":false},{"id":85407,"name":"Eric B. Durbin","orcid":"0000-0002-5600-7645","position":5,"is_corresponding":false},{"id":519711,"name":"T. C. Tucker","orcid":"0000-0002-5993-484X","position":6,"is_corresponding":false},{"id":250644,"name":"Eric Tai","orcid":"0000-0001-5184-9037","position":7,"is_corresponding":false},{"id":355412,"name":"Bin Huang","orcid":"0000-0002-9075-1531","position":8,"is_corresponding":false},{"id":355410,"name":"Feitong Lei","orcid":"0000-0002-1757-4858","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"37063057","pmcid":"PMC11106759","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}