{"doi":"10.1002/cncr.34531","title":"Associations of device‐measured physical activity and sedentary time with quality of life and fatigue in newly diagnosed breast cancer patients: Baseline results from the AMBER cohort study","abstract":"BACKGROUND: This study examined associations of device-measured physical activity and sedentary time with quality of life (QOL) and fatigue in newly diagnosed breast cancer patients in the Alberta Moving Beyond Breast Cancer (AMBER) cohort study. METHODS: After diagnosis, 1409 participants completed the SF-36 version 2 and the Fatigue Scale, wore an ActiGraph device on their right hip to measure physical activity, and an activPAL device on their thigh to measure sedentary time (sitting/lying) and steps. ActiGraph data was analyzed using a hybrid machine learning method (R Sojourn package, Soj3x) and activPAL data were analyzed using activPAL algorithms (PAL Software version 8). Quantile regression was used to examine cross-sectional associations of QOL and fatigue with steps, physical activity, and sedentary hours at the 25th, 50th, and 75th percentiles of the QOL and fatigue distributions. RESULTS: Total daily moderate and vigorous physical activity (MVPA) hours was positively associated with better physical QOL at the 25th (β = 2.14, p = <.001), 50th (β = 1.98, p = <.001), and 75th percentiles (β = 1.25, p = .003); better mental QOL at the 25th (β = 1.73, p = .05) and 50th percentiles (β = 1.07, p = .03); and less fatigue at the 25th (β = 4.44, p < .001), 50th (β = 3.08, p = <.001), and 75th percentiles (β = 1.51, p = <.001). Similar patterns of associations were observed for daily steps. Total sedentary hours was associated with worse fatigue at the 25th (β = -0.58, p = .05), 50th (β = -0.39, p = .06), and 75th percentiles (β = -0.24, p = .02). Sedentary hours were not associated with physical or mental QOL. CONCLUSIONS: MVPA and steps were associated with better physical and mental QOL and less fatigue in newly diagnosed breast cancer patients. Higher sedentary time was associated with greater fatigue symptoms.","journal":"Cancer","year":2022,"id":254872,"datarank":0.6550762834610779,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.19141991545733048,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.19141991545733048,"corpus_percentile":69.59851473659782,"corpus_rank":3931,"citation_count":21,"citer_count":14,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5121,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":24242,"name":"Christine M. Friedenreich","orcid":"0000-0002-4783-1966","position":1,"is_corresponding":false},{"id":902114,"name":"Qinggang Wang","orcid":"0000-0002-3975-1560","position":2,"is_corresponding":false},{"id":231465,"name":"Charles E. Matthews","orcid":"0000-0001-8037-3103","position":3,"is_corresponding":false},{"id":284198,"name":"Lin Yang","orcid":"0000-0002-1698-6666","position":4,"is_corresponding":false},{"id":902115,"name":"Margaret L. McNeely","orcid":"0000-0003-4376-4847","position":5,"is_corresponding":false},{"id":902116,"name":"S. Nicole Culos‐Reed","orcid":"0000-0003-3896-7383","position":6,"is_corresponding":false},{"id":902117,"name":"Gordon J. Bell","orcid":"0000-0003-1884-0924","position":7,"is_corresponding":false},{"id":902118,"name":"Andria R. Morielli","orcid":"0000-0002-5367-635X","position":8,"is_corresponding":false},{"id":902119,"name":"Jessica McNeil","orcid":"0000-0002-1078-5812","position":9,"is_corresponding":false},{"id":902549,"name":"Leanne Dickau","orcid":null,"position":10,"is_corresponding":false},{"id":403902,"name":"Diane J. Cook","orcid":"0000-0002-4441-7508","position":11,"is_corresponding":false},{"id":512002,"name":"Kerry S. Courneya","orcid":"0000-0002-9677-3918","position":12,"is_corresponding":false},{"id":902113,"name":"Jeff K. Vallance","orcid":"0000-0003-1135-8772","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:25:08.518416Z","pmid":"36367438","pmcid":"PMC10695099","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}