{"doi":"10.1002/cncr.33986","title":"Self‐help smoking cessation intervention for Spanish‐speaking Hispanics/Latinxs in the United States: A randomized controlled trial","abstract":"BACKGROUND: Hispanic/Latinx smokers living in the United States face unique challenges in quitting smoking. This study evaluated the efficacy of a culturally relevant, Spanish-language, extended self-help smoking cessation intervention among Hispanic smokers. METHODS: A 2-arm parallel randomized controlled trial was conducted with Hispanic/Latinx smokers living in the United States who preferred health information in Spanish and smoked 5 or more cigarettes per week. Participants were randomly allocated to receive Libre del Cigarrillo (LDC), which consisted of 11 booklets and 9 pamphlets mailed monthly over 18 months, or the usual care (UC), which was a single Spanish-language self-help booklet from the National Cancer Institute. The primary outcome was self-reported 7-day point prevalence smoking abstinence assessed 6, 12, 18, and 24 months after the baseline. Eight prespecified moderators of the intervention were evaluated. Cost-effectiveness was also evaluated. All statistical tests were 2-sided. RESULTS: Data from all participants randomized to LDC (n = 714) or UC (n = 703) were used for analyses after multiple imputation to manage missing data. Generalized estimating equation analyses indicated that LDC abstinence rates were higher (P < .001) across all assessments. Logistic regression analyses revealed that at 24 months, the abstinence rate was greater for LDC (33.1%) than UC (24.3%; odds ratio, 1.54; 95% confidence interval, 1.18-2.02; P = .002). Men exhibited a strong intervention effect at all assessments (P values < .001), whereas the intervention effect for women was observed only at 6 and 12 months (P values < .018). In comparison with UC, the incremental cost per quitter in the LDC arm was $648.43 at 18 months and $683.93 at 24 months. CONCLUSIONS: A culturally relevant, Spanish-language intervention was efficacious and cost-effective for smoking cessation. LAY SUMMARY: Research is needed to develop interventions for ethnic minority smokers. The aim of the current study was to test a Spanish-language adaptation of a validated and easily implemented self-help smoking cessation intervention in a nationwide randomized controlled trial. The findings demonstrated that the intervention produced greater smoking abstinence in comparison with a standard self-help booklet. Participants also were more satisfied with the intervention, and it was cost-effective. Efforts aimed at promoting tobacco abstinence in this underserved population could have significant public health implications, including potential reductions in cancer health disparities associated with tobacco smoking.","journal":"Cancer","year":2021,"id":172014,"datarank":0.9548373029936883,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.4604617730930388,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.4604617730930388,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":23,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02945787"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":399199,"name":"Steven K. Sutton","orcid":"0000-0002-2504-7601","position":1,"is_corresponding":false},{"id":439452,"name":"Patricia Medina-Ramírez","orcid":"0000-0002-8047-856X","position":2,"is_corresponding":false},{"id":399201,"name":"Úrsula Martínez","orcid":"0000-0002-4212-5851","position":3,"is_corresponding":false},{"id":439454,"name":"Karen O. Brandon","orcid":"0000-0003-3948-5650","position":4,"is_corresponding":false},{"id":439455,"name":"Margaret M. Byrne","orcid":"0000-0002-8143-4702","position":5,"is_corresponding":false},{"id":399203,"name":"Cathy D. Meade","orcid":"0000-0001-6422-8248","position":6,"is_corresponding":false},{"id":399200,"name":"Lauren R. Meltzer","orcid":"0000-0001-7600-6829","position":7,"is_corresponding":false},{"id":399204,"name":"Thomas H. Brandon","orcid":"0000-0003-1559-5679","position":8,"is_corresponding":false},{"id":399198,"name":"Vani N. Simmons","orcid":"0000-0002-4381-5336","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-18T23:46:37.150824Z","pmid":"34679188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}