{"doi":"10.1002/cncr.33824","title":"Active surveillance for intermediate‐risk prostate cancer in African American and non‐Hispanic White men","abstract":"BACKGROUND: The safety of active surveillance (AS) for African American men compared with non-Hispanic White (White) men with intermediate-risk prostate cancer is unclear. METHODS: The authors identified patients with modified National Comprehensive Cancer Network favorable (\"low-intermediate\") and unfavorable (\"high-intermediate\") intermediate-risk prostate cancer diagnosed between 2001 and 2015 and initially managed with AS in the Veterans Health Administration database. They analyzed definitive treatment, disease progression, metastases, prostate cancer-specific mortality (PCSM), and all-cause mortality by using cumulative incidences and multivariable competing-risks (disease progression, metastasis, and PCSM) or Cox (all-cause mortality) regression. RESULTS: The cohort included 1007 men (African Americans, 330 [32.8%]; Whites, 677 [67.2%]) followed for a median of 7.7 years; 773 (76.8%) had low-intermediate-risk disease, and 234 (23.2%) had high-intermediate-risk disease. The 10-year cumulative incidences of definitive treatment were not significantly different (African Americans, 83.5%; 95% confidence interval [CI], 78.5%-88.7%; Whites, 80.6%; 95% CI, 76.6%-84.4%; P = .17). Among those with low-intermediate-risk disease, there were no significant differences in the 10-year cumulative incidences of disease progression (African Americans, 46.8%; 95% CI, 40.0%-53.3%; Whites, 46.9%; 95% CI, 42.1%-51.5%; P = .91), metastasis (African Americans, 7.1%; 95% CI, 3.7%-11.8%; Whites, 10.8%; 95% CI, 7.6%-14.6%; P = .17), or PCSM (African Americans, 3.8%; 95% CI, 1.6%-7.5%; Whites, 3.8%; 95% CI, 2.0%-6.3%; P = .69). In a multivariable regression including the entire cohort, African American race was not associated with increased risks of definitive treatment, disease progression, metastasis, PCSM, or all-cause mortality (all P > .30). CONCLUSIONS: Outcomes in the Veterans Affairs Health System were similar for African American and White men treated for low-intermediate-risk prostate cancer with AS.","journal":"Cancer","year":2021,"id":200350,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6807,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263867,"name":"Rishi Deka","orcid":"0000-0002-7783-0016","position":1,"is_corresponding":false},{"id":689765,"name":"Nikhil V. Kotha","orcid":"0000-0001-9737-5033","position":2,"is_corresponding":false},{"id":554705,"name":"Daniel Cherry","orcid":"0000-0002-6441-9172","position":3,"is_corresponding":false},{"id":488829,"name":"Mia Salans","orcid":"0000-0002-5195-5590","position":4,"is_corresponding":false},{"id":738345,"name":"Tyler J. Nelson","orcid":"0000-0001-5216-7337","position":5,"is_corresponding":false},{"id":263865,"name":"Abhishek Kumar","orcid":"0000-0002-2306-8863","position":6,"is_corresponding":false},{"id":265415,"name":"Elaine Luterstein","orcid":null,"position":7,"is_corresponding":false},{"id":390740,"name":"Anthony Yip","orcid":"0000-0002-3232-1357","position":8,"is_corresponding":false},{"id":537924,"name":"Vinit Nalawade","orcid":"0000-0002-6594-6740","position":9,"is_corresponding":false},{"id":383754,"name":"J. Kellogg Parsons","orcid":"0000-0002-3676-9730","position":10,"is_corresponding":false},{"id":383755,"name":"A. Karim Kader","orcid":"0009-0007-5296-197X","position":11,"is_corresponding":false},{"id":345037,"name":"Tyler F. Stewart","orcid":"0000-0002-8170-264X","position":12,"is_corresponding":false},{"id":263871,"name":"Brent S. Rose","orcid":"0000-0002-3197-9552","position":13,"is_corresponding":false},{"id":369812,"name":"P.T. Courtney","orcid":"0000-0001-7625-3678","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:50:48.624274Z","pmid":"34347291","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}