{"doi":"10.1002/cncr.33582","title":"Prevalence of human papillomavirus genotypes in high‐grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States","abstract":"BACKGROUND: US population-based cancer registries can be used for surveillance of human papillomavirus (HPV) types found in HPV-associated cancers. Using this framework, HPV prevalence among high-grade cervical precancers and invasive cervical cancers were compared before and after HPV vaccine availability. METHODS: Archived tissue from 2 studies of cervical precancers and invasive cervical cancers diagnosed from 1993-2005 (prevaccine) were identified from 7 central cancer registries in Florida; Hawaii; Iowa; Kentucky; Louisiana; Los Angeles County, California; and Michigan; from 2014 through 2015 (postvaccine) cases were identified from 3 registries in Iowa, Kentucky, and Louisiana. HPV testing was performed using L1 consensus polymerase chain reaction analysis. HPV-type-specific prevalence was examined grouped by hierarchical attribution to vaccine types: HPV 16, 18, HPV 31, 33, 45, 52, 58, other oncogenic HPV types, and other types/HPV negative. Generalized logit models were used to compare HPV prevalence in the prevaccine study to the postvaccine study by patient age, adjusting for sampling factors. RESULTS: A total of 676 precancers (328 prevaccine and 348 postvaccine) and 1140 invasive cervical cancers (777 prevaccine and 363 postvaccine) were typed. No differences were observed in HPV-type prevalence by patient age between the 2 studies among precancers or invasive cancers. CONCLUSIONS: The lack of reduction in vaccine-type prevalence between the 2 studies is likely explained by the low number of cases and low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies will continue to be important in evaluating the impact of the HPV vaccine.","journal":"Cancer","year":2021,"id":202629,"datarank":0.3973887430006987,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.10550222064240164,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.10550222064240164,"corpus_percentile":54.018720507465,"corpus_rank":5945,"citation_count":6,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":272057,"name":"Mona Saraiya","orcid":"0000-0002-4527-828X","position":1,"is_corresponding":false},{"id":24216,"name":"Trevor Thompson","orcid":"0000-0001-9880-782X","position":2,"is_corresponding":false},{"id":355570,"name":"Troy D. Querec","orcid":"0000-0002-3787-6271","position":3,"is_corresponding":false},{"id":782755,"name":"April Greek","orcid":"0000-0003-4253-7511","position":4,"is_corresponding":false},{"id":519711,"name":"T. C. Tucker","orcid":"0000-0002-5993-484X","position":5,"is_corresponding":false},{"id":71800,"name":"Edward Peters","orcid":"0000-0003-4928-6532","position":6,"is_corresponding":false},{"id":353157,"name":"Charles F. Lynch","orcid":"0000-0002-9542-6439","position":7,"is_corresponding":false},{"id":33564,"name":"Brenda Y. Hernandez","orcid":"0000-0003-0132-4042","position":8,"is_corresponding":false},{"id":782756,"name":"Glenn Copeland","orcid":"0000-0002-0141-0541","position":9,"is_corresponding":false},{"id":33585,"name":"Marc T. Goodman","orcid":"0000-0002-4839-3021","position":10,"is_corresponding":false},{"id":355575,"name":"Elizabeth R. Unger","orcid":"0000-0002-2925-5635","position":11,"is_corresponding":false},{"id":272055,"name":"Jacqueline Mix","orcid":"0000-0001-6418-7706","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T23:51:10.291262Z","pmid":"34289090","pmcid":"PMC10084843","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}