{"doi":"10.1002/cncr.32769","title":"Significance of minimal residual disease monitoring by real‐time quantitative polymerase chain reaction in core binding factor acute myeloid leukemia for transplantation outcomes","abstract":"BACKGROUND: Despite the well-defined role of minimal residual disease (MRD) monitoring by real-time quantitative polymerase chain reaction (RT-PCR) for RUNX1/RUNX1T1 and CBFB-MYH11 transcripts in core binding factor (CBF) acute myeloid leukemia (AML) after intensive chemotherapy, there has been a paucity of data assessing the utility of MRD monitoring at and after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: Patients with CBF AML who underwent HSCT in complete remission (first or second) from January 2007 through December 2018 were included in this analysis. RESULTS: MRD by polymerase chain reaction at HSCT was assessed in 50 of 76 patients, and 44 (88%) had evidence of MRD (MRDpos). MRDpos patients had 3-year overall survival (OS) and leukemia-free survival (LFS) rates of 69.3% and 66.3%, respectively. Six MRD-negative patients had 3-year OS and LFS rates of 100% and 100%, respectively. Thirty-five of the 70 evaluable patients (50%) had a day +100 MRD assessment by RT-PCR, and 14 (40%) were MRDpos. The presence of MRD by RT-PCR on day +100 was not associated with lower estimates of LFS (75% vs 82.2%; P = .3) but was associated with a higher relapse incidence, although the difference did not reach statistical significance (27.6% vs 9.7%; P = .2). CONCLUSIONS: Durable complete remissions can be achieved in patients with CBF AML with HSCT even if they are MRDpos by RT-PCR at HSCT. The clinical impact of frequent MRD monitoring for identifying a group at high risk for early relapse and then for determining the best time point for therapeutic interventions to prevent impending relapse warrants investigation in prospectively designed clinical trials.","journal":"Cancer","year":2020,"id":96342,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":33069,"name":"Keyur P. Patel","orcid":"0000-0001-5081-2427","position":1,"is_corresponding":false},{"id":339779,"name":"Qaiser Bashir","orcid":"0000-0002-4086-6453","position":2,"is_corresponding":false},{"id":18382,"name":"David Marín","orcid":"0000-0003-0812-9346","position":3,"is_corresponding":false},{"id":247184,"name":"Sairah Ahmed","orcid":"0000-0001-7302-8299","position":4,"is_corresponding":false},{"id":90479,"name":"Amin M. Alousi","orcid":"0000-0002-2498-8573","position":5,"is_corresponding":false},{"id":478283,"name":"Julianne Chen","orcid":null,"position":6,"is_corresponding":false},{"id":313714,"name":"Stefan O. Ciurea","orcid":"0000-0001-8597-3271","position":7,"is_corresponding":false},{"id":478284,"name":"Katy Rezvani","orcid":null,"position":8,"is_corresponding":false},{"id":284154,"name":"Uday Popat","orcid":"0000-0002-7592-2224","position":9,"is_corresponding":false},{"id":18375,"name":"Elizabeth J. Shpall","orcid":"0000-0003-3947-4126","position":10,"is_corresponding":false},{"id":18374,"name":"Richard E. Champlin","orcid":"0000-0002-4314-5037","position":11,"is_corresponding":false},{"id":348679,"name":"Betül Oran","orcid":"0000-0003-1264-5968","position":12,"is_corresponding":false},{"id":477564,"name":"Fevzi Yalniz","orcid":"0000-0003-3569-8632","position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32101640","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}