{"doi":"10.1002/cmdc.202500532","title":"A Short Peptide Inhibitor of Measles Virus Fusion Protein that Exhibits Passive Membrane Permeability","abstract":"In this study, a passively membrane‐permeable short peptide inhibitor targeting the measles virus fusion protein (MeV‐F) is reported. Measles virus (MeV) is highly contagious, yet no approved antiviral drugs are currently available. MeV‐F plays a crucial role in viral infection, making it an attractive target for drug development. The fusion inhibitor peptide (FIP) is a well‐known short peptide that binds to MeV‐F and prevents its structural rearrangement. However, improving both inhibitory activity and passive membrane permeability is essential for developing orally available MeV‐F inhibitors. Herein, FIP derivatives are explored through hydrogen‐to‐fluorine substitution and a derivative with enhanced inhibitory activity (IC 50 = 90 nM) and passive membrane permeability ( P e = 1.4 × 10 –6 cm s −1 ) was identified. This study highlights the potential of the long‐studied fusion inhibitor peptide as a promising lead compound for the development of orally available drugs against measles infection.","journal":"ChemMedChem","year":2025,"id":571183,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1477034,"name":"Jiei Sasaki","orcid":"0000-0002-5129-2336","position":1,"is_corresponding":false},{"id":1443638,"name":"Tateki Suzuki","orcid":"0000-0002-6946-3850","position":2,"is_corresponding":false},{"id":496298,"name":"Shinsuke Sando","orcid":"0000-0003-0275-7237","position":3,"is_corresponding":false},{"id":697979,"name":"Takao Hashiguchi","orcid":"0000-0001-7578-7571","position":4,"is_corresponding":false},{"id":724180,"name":"Jumpei Morimoto","orcid":"0000-0002-8393-9616","position":5,"is_corresponding":false},{"id":1477033,"name":"Ziwei Gao","orcid":"0009-0008-7233-3687","position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T02:57:15.755535Z","pmid":"40720755","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}