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These efforts culminated in the discovery of <jats:italic>N</jats:italic>‐(2,4‐dimethylphenyl)‐<jats:italic>N</jats:italic>‐isobutyl‐2‐oxo‐1‐[(tetrahydro‐2<jats:italic>H</jats:italic>‐pyran‐4‐yl)methyl]‐2,3‐dihydro‐1<jats:italic>H</jats:italic>‐benzo[<jats:italic>d</jats:italic>]imidazole‐5‐sulfonamide (CD12681), a potent inverse agonist with in vivo activity in an IL‐23‐induced mouse skin inflammation 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