{"doi":"10.1002/cm.21053","title":"Anterior PAR proteins function during cytokinesis and maintain DYN‐1 at the cleavage furrow in <i>Caenorhabditis elegans</i>","abstract":"<jats:title>Abstract</jats:title><jats:p>PAR proteins are key regulators of cellular polarity and have links to the endocytic machinery and the actin cytoskeleton. Our data suggest a unique role for PAR proteins in cytokinesis. We have found that at the onset of cytokinesis, anterior PAR‐6 and posterior PAR‐2 proteins are redistributed to the furrow membrane in a temporal and spatial manner. PAR‐6 and PAR‐2 localize to the furrow membrane during ingression but PAR‐2‐GFP is distinct in that it is excluded from the extreme tip of the furrow. Once the midbody has formed, PAR‐2‐GFP becomes restricted to the midbody region (the midbody plus the membrane flanking it). Depletion of both anterior PAR proteins, PAR‐3 and PAR‐6, led to an increase in multinucleate embryos, suggesting that the anterior PAR proteins are necessary during cytokinesis and that PAR‐3 and PAR‐6 function in cytokinesis may be partially redundant. Lastly, anterior PAR proteins play a role in the maintenance of DYN‐1 in the cleavage furrow. Our data indicate that the PAR proteins are involved in the events that occur during cytokinesis and may play a role in promoting the membrane trafficking and remodeling events that occur during this time. © 2012 Wiley Periodicals, Inc</jats:p>","journal":"Cytoskeleton","year":2012,"id":41992,"datarank":0.4803377110120489,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.16842147976007346,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.16842147976007346,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":201547,"name":"Ahna R. 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