{"doi":"10.1002/chem.202402302","title":"Development of Low‐Toxicity Antimicrobial Polycarbonates Bearing Lysine Residues.","abstract":"Antibiotic resistance has been threatening public health for a long period, while the COVID pandemic aggravated the scenario. To combat antibiotic resistance strains, host defense peptides (HDPs) mimicking molecules have attracted considerable attention. Herein, we reported a series of polycarbonates bearing cationic lysine amino acid residues that could mimic the mechanism of action of HDPs and possess broad-spectrum antimicrobial activity. Moreover, those polymers had negligible toxicity toward red blood cells and mammalian cells. The membrane-disruption mechanism endows the lysine-containing polycarbonates with low possibility of resistance development and the fast killing kinetics, making them promising candidates for antimicrobial development.","journal":"Chemistry - A European Journal","year":2024,"id":481602,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9465,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":951454,"name":"Menglin Xue","orcid":null,"position":1,"is_corresponding":false},{"id":399643,"name":"Ning Shen","orcid":"0000-0003-4709-3374","position":2,"is_corresponding":false},{"id":1066989,"name":"Xue Zhao","orcid":"0000-0001-9281-7680","position":3,"is_corresponding":false},{"id":1322018,"name":"Justin C Zhang","orcid":null,"position":4,"is_corresponding":false},{"id":436096,"name":"Chuanhai Cao","orcid":"0000-0002-5765-6401","position":5,"is_corresponding":false},{"id":300813,"name":"Jianfeng Cai","orcid":"0000-0003-3106-3306","position":6,"is_corresponding":false},{"id":261770,"name":"Ruixuan Gao","orcid":"0000-0001-7137-2512","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:07:10.067421Z","pmid":"39327935","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}