{"doi":"10.1002/chem.202202397","title":"Phomoxanthone A Targets ATP Synthase","abstract":"Phomoxanthone A is a naturally occurring molecule and a powerful anti-cancer agent, although its mechanism of action is unknown. To facilitate the determination of its biological target(s), we used affinity-based labelling using a phomoxanthone A probe. Labelled proteins were pulled down, subjected to chemoproteomics analysis using LC-MS/MS and ATP synthase was identified as a likely target. Mitochondrial ATP synthase was validated in cultured cells lysates and in live intact cells. Our studies show sixty percent inhibition of ATP synthase by 260 μM phomoxanthone A.","journal":"Chemistry - A European Journal","year":2022,"id":291366,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9613,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":689955,"name":"Sangram S. Parelkar","orcid":null,"position":1,"is_corresponding":false},{"id":109690,"name":"Paul R. Thompson","orcid":"0000-0002-1621-3372","position":2,"is_corresponding":false},{"id":975112,"name":"Susan Mitroka‐Batsford","orcid":null,"position":3,"is_corresponding":false},{"id":975113,"name":"Siddartha Yerramilli","orcid":null,"position":4,"is_corresponding":false},{"id":403907,"name":"Suzanne Scarlata","orcid":"0000-0001-5652-7467","position":5,"is_corresponding":false},{"id":805978,"name":"Katelyn S. Mistretta","orcid":null,"position":6,"is_corresponding":false},{"id":381606,"name":"Jeannine M. Coburn","orcid":"0000-0001-6354-5436","position":7,"is_corresponding":false},{"id":299717,"name":"Anita E. Mattson","orcid":"0000-0003-4662-3468","position":8,"is_corresponding":false},{"id":704471,"name":"Rameez Ali","orcid":null,"position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:30:38.420009Z","pmid":"36082977","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}