{"doi":"10.1002/ccs3.70003","title":"CCN2 functions as a modulator of cell cycle regulation in human dermal fibroblasts","abstract":"CCN2 is widely regarded as a profibrotic factor involved in fibrotic disorders by regulating extracellular matrix (ECM). We report here that CCN2 functions as a critical cell cycle regulator in primary human dermal fibroblasts (HDFs). siRNA-mediated knockdown of CCN2 halted proliferation of primary HDFs, which was rescued by a siRNA-resistant CCN2 expression vector. Furthermore, CCN2 knockdown caused a significant accumulation of cells in G1/G0 phase and blocked entry into S-phase. Mechanistically, CCN2 knockdown blocked cyclin E and CDK4/cyclin D nuclear translocation, and abrogated CDK2 activity. Markedly, CCN2 translocated to the nucleus and co-localized with cyclin D1 upon cell cycle stimulation. Finally, we show that CCN2, a bona fide YAP/TAZ target gene, partially mediates YAP/TAZ-dependent proliferation of primary HDFs. These data provide evidence of a novel CCN2 function as a cell cycle regulator in primary HDFs proliferation, in addition to its known role in ECM regulation.","journal":"Journal of Cell Communication and Signaling","year":2025,"id":542962,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1278706,"name":"Yuan Shao","orcid":null,"position":1,"is_corresponding":false},{"id":262015,"name":"Trupta Purohit","orcid":"0000-0003-0697-4140","position":2,"is_corresponding":false},{"id":1432730,"name":"Yiou Jiang","orcid":null,"position":3,"is_corresponding":false},{"id":728522,"name":"Zhaoping Qin","orcid":"0000-0003-2439-5417","position":4,"is_corresponding":false},{"id":252050,"name":"Gary J. Fisher","orcid":"0000-0002-6065-6242","position":5,"is_corresponding":false},{"id":1432397,"name":"Nathan H. Lents","orcid":"0000-0003-1509-6415","position":6,"is_corresponding":false},{"id":1432731,"name":"Joseph J. Baldassare","orcid":null,"position":7,"is_corresponding":false},{"id":252049,"name":"Taihao Quan","orcid":"0000-0002-0954-5109","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T02:53:00.171379Z","pmid":"39898007","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}