{"doi":"10.1002/cbic.202500366","title":"Reductant‐ or Light‐Driven ATP‐Independent Reduction of CO<sub>2</sub> by Nitrogenase MoFe Protein","abstract":"Nitrogenase is a versatile metalloenzyme that activates and reduces small molecules like N 2 , CO, and CO 2 into value‐added chemicals at ambient conditions. Previously, it is shown that the Mo‐nitrogenase could reduce CO 2 to CO, but not to hydrocarbons, in an ATP‐dependent reaction. Here, it is reported that the ability of the catalytic component of Mo‐nitrogenase (MoFe protein) enables ATP‐independent reduction of CO 2 to up to C 4 hydrocarbons in room‐temperature reactions driven by a chemical reductant (Eu II –DTPA) or visible light (via CdS@ZnS (CZS) quantum dots). Moreover, an opposite deuterium isotope effect is observed on the Eu II –DTPA driven reactions of CO 2 reduction by MoFe protein and its V‐counterpart (VFe protein), in that the former displays higher activities in H 2 O, and the latter displays higher activities in D 2 O. These results provide an important foundation for further mechanistic exploration of the nitrogenase‐enabled, atypical Fischer–Tropsch type reaction that uses CO 2 instead of CO as a substrate; moreover, they serves as a potential template for the future development of nitrogenase‐based applications that effectively recycle the greenhouse gas CO 2 into valuable fuel products.","journal":"ChemBioChem","year":2025,"id":568543,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":392491,"name":"Yilin Hu","orcid":"0000-0002-9088-2865","position":1,"is_corresponding":false},{"id":392492,"name":"Markus W. Ribbe","orcid":"0000-0002-7366-1526","position":2,"is_corresponding":false},{"id":873890,"name":"Chi Chung Lee","orcid":"0000-0001-9365-9397","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T02:56:52.212268Z","pmid":"40523157","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}