{"doi":"10.1002/cbic.202000162","title":"Tuning the Innate Immune Response to Cyclic Dinucleotides by Using Atomic Mutagenesis","abstract":"Cyclic dinucleotides (CDNs) trigger the innate immune response in eukaryotic cells through the stimulator of interferon genes (STING) signaling pathway. To decipher this complex cellular process, a better correlation between structure and downstream function is required. Herein, we report the design and immunostimulatory effect of a novel group of c-di-GMP analogues. By employing an \"atomic mutagenesis\" strategy, changing one atom at a time, a class of gradually modified CDNs was prepared. These c-di-GMP analogues induce type-I interferon (IFN) production, with some being more potent than c-di-GMP, their native archetype. This study demonstrates that CDN analogues bearing modified nucleobases are able to tune the innate immune response in eukaryotic cells.","journal":"ChemBioChem","year":2020,"id":109560,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":522384,"name":"Andréa Fin","orcid":"0000-0002-7567-4646","position":1,"is_corresponding":false},{"id":522385,"name":"Alexander R. Rovira","orcid":"0000-0002-7806-7593","position":2,"is_corresponding":false},{"id":245564,"name":"Yichi Su","orcid":"0000-0001-5715-835X","position":3,"is_corresponding":false},{"id":522386,"name":"Andrew Dippel","orcid":"0000-0003-3453-0803","position":4,"is_corresponding":false},{"id":522387,"name":"J. Andrés Valderrama","orcid":"0000-0001-7440-4225","position":5,"is_corresponding":false},{"id":490430,"name":"Angelica M. Riestra","orcid":"0000-0002-7856-2607","position":6,"is_corresponding":false},{"id":225262,"name":"Victor Nizet","orcid":"0000-0003-3847-0422","position":7,"is_corresponding":false},{"id":522388,"name":"Ming C. Hammond","orcid":"0000-0003-2666-4764","position":8,"is_corresponding":false},{"id":327158,"name":"Yitzhak Tor","orcid":"0000-0003-3726-7799","position":9,"is_corresponding":false},{"id":522383,"name":"Yao Li","orcid":"0000-0003-4741-4799","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-18T23:12:50.712357Z","pmid":"32346955","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}