{"doi":"10.1002/cbic.202000056","title":"Responsive Fluorophore Aggregation Provides Spectral Contrast for Fluorescence Lifetime Imaging","abstract":"Fluorophores experience altered emission lifetimes when incorporated into and liberated from macromolecules or molecular aggregates; this trend suggests the potential for a fluorescent, responsive probe capable of undergoing self-assembly and aggregation and consequently altering the lifetime of its fluorescent moiety to provide contrast between the active and inactive probes. We developed a cyanobenzothioazole-fluorescein conjugate (1), and spectroscopically examined the lifetime changes caused by its reduction-induced aggregation in vitro. A decrease in lifetime was observed for compound 1 in a buffered system activated by the biological reducing agent glutathione, thus suggesting a possible approach for designing responsive self-aggregating lifetime imaging probes.","journal":"ChemBioChem","year":2020,"id":87352,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":444076,"name":"Benjamin D. Datko","orcid":"0000-0002-6278-4328","position":1,"is_corresponding":false},{"id":444077,"name":"Brandon Burnside","orcid":"0000-0003-2415-9916","position":2,"is_corresponding":false},{"id":371032,"name":"Chao Cui","orcid":"0000-0003-1154-0929","position":3,"is_corresponding":false},{"id":444078,"name":"Xiaowei Ma","orcid":"0000-0003-0352-5809","position":4,"is_corresponding":false},{"id":444079,"name":"John K. Grey","orcid":"0000-0001-7307-8894","position":5,"is_corresponding":false},{"id":371034,"name":"Lina Cui","orcid":"0000-0002-8149-5206","position":6,"is_corresponding":false},{"id":371028,"name":"Kelton A. Schleyer","orcid":"0000-0001-5385-8850","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T21:59:31.247492Z","pmid":"32180309","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}