{"doi":"10.1002/cbf.290050104","title":"Differential hemoglobin synthesis in murino erythroleukemic cells: Hemin effects","abstract":"<jats:title>Abstract</jats:title><jats:p>The addition of butyric acid to murine erythroleukemic cells (clone T3C12) induced the cells to differentiate, producing adult hemoglobin (A, α<jats:sub>2</jats:sub>,β<jats:sub>2</jats:sub>) and an embryonic hemoglobin (E<jats:sub>2</jats:sub>, α<jats:sub>2</jats:sub>Y<jats:sub>2</jats:sub>). The subsequent addition of hemin to the differentiating cells increased the synthesis of adult hemoglobin four‐fold and the synthesis of embryonic hemoglobin two‐fold; the relative synthesis of the α and β globins increased more than the Y globin. The embyronic hemoglobin was expressed prior to the adult hemoglobin in differentiating cells.</jats:p>","journal":"Cell Biochemistry and Function","year":1987,"id":652881,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1703346,"name":"M. E. 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The subsequent addition of hemin to the differentiating cells increased the synthesis of adult hemoglobin four‐fold and the synthesis of embryonic hemoglobin two‐fold; the relative synthesis of the α and β globins increased more than the Y globin. The embyronic hemoglobin was expressed prior to the adult hemoglobin in differentiating cells.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3469035","pmcid":null,"openalex_id":"https://openalex.org/W2082122433","authors":[],"funders":[{"funder_name":"NCRR NIH HHS","grant_id":"RR 05690","title":null},{"funder_name":"PHS HHS","grant_id":"24165","title":null}],"total_grants":2,"fwci":0.0,"citation_percentile":0.13456464,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcbf.290050104","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/cbf.290050104","host_type":"publisher"},{"url":"https://doi.org/10.1002/cbf.290050104","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3469035","host_type":"repository"}],"fields_of_study":["Hemoglobin structure and function","Hemoglobinopathies and Related Disorders","Erythrocyte Function and Pathophysiology","Animals","Butyrates","Butyric Acid","Cell Differentiation","Clone Cells","Friend murine leukemia virus","Heme","Hemin","Hemoglobins","Isoniazid","Leukemia, Erythroblastic, Acute","Leukemia, Experimental","Mice"],"mesh_terms":["Animals","Butyrates","Cell Differentiation","Clone Cells","Leukemia, Erythroblastic, Acute","Friend murine leukemia virus","Heme","Hemin","Hemoglobins","Isoniazid","Leukemia, Experimental","Butyric Acid","Mice"],"keywords":["Hemin","Hemoglobin","Globin","Embryonic stem cell","clone (Java method)","Biology","BETA (programming language)","Alpha (finance)","Molecular biology","Butyric acid","Hemoglobin A","Biochemistry","Chemistry","Gene","Heme","Enzyme","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T17:21:30.444788Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}