{"doi":"10.1002/cam4.71305","title":"Clinical Significance and Therapeutic Potential of Long Non‐Coding RNA H19 in Soft Tissue Sarcoma","abstract":"<h4>Background</h4>Long non-coding RNA (lncRNA) H19 plays a pivotal role in the pathogenesis of different human cancers, but its role in soft tissue sarcoma (STS) has not yet been defined.<h4>Methods</h4>We analyzed H19 expression patterns in various cancer cell lines, focusing on sarcoma subtypes. RNA in situ hybridization was performed on a tissue microarray (n = 150) to assess H19 expression in human STS samples. Univariate and multivariate analyses were conducted to evaluate H19's prognostic value. In STS cell lines with high H19 expression, a Gapmer-based knock-down approach was used to study the functional impact of H19 expression.<h4>Results</h4>Low H19 expression was associated with poor prognosis in univariate analysis (HR: 0.564; 95% CI: 0.324-0.985; p = 0.044). Multivariate analysis showed advanced patient age (p < 0.001) and large tumor size (p = 0.002) as independent predictors of worse overall survival, irrespective of H19 expression (HR: 0.655; 95% CI: 0.367-1.170; p = 0.153). H19 knockdown in STS cell lines reduced cellular growth and increased pro-apoptotic activity.<h4>Discussion</h4>Our findings suggest that H19 might play a role in STS pathogenesis. While its prognostic value requires further investigation, H19-based targeting approaches may warrant evaluation for therapeutic potential in STS.","journal":"Cancer Medicine","year":2026,"id":12446,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.139,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2026-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":98120,"name":"Katarina Krajina","orcid":null,"position":1,"is_corresponding":false},{"id":98121,"name":"Maria Anna Smolle","orcid":"0000-0003-1021-0899","position":2,"is_corresponding":false},{"id":98122,"name":"Dimyana Neufeldt","orcid":null,"position":3,"is_corresponding":false},{"id":98123,"name":"Katharina Jonas","orcid":"0000-0003-1855-9411","position":4,"is_corresponding":false},{"id":98124,"name":"Beate Rinner","orcid":null,"position":5,"is_corresponding":false},{"id":98125,"name":"Kevin Mellert","orcid":"0000-0001-6338-1857","position":6,"is_corresponding":false},{"id":98126,"name":"Maxim Noeparast","orcid":"0000-0002-3216-5630","position":7,"is_corresponding":false},{"id":98127,"name":"Martin Trepel","orcid":null,"position":8,"is_corresponding":false},{"id":98128,"name":"Joanna Szkandera","orcid":"0000-0002-2217-893X","position":9,"is_corresponding":false},{"id":98129,"name":"Martin Pichler","orcid":"0000-0002-8701-9462","position":10,"is_corresponding":false},{"id":98130,"name":"Bernadette Liegl‐Azwanger","orcid":null,"position":11,"is_corresponding":false},{"id":98119,"name":"Stephan Jahn","orcid":"0000-0002-0330-0274","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}