{"doi":"10.1002/cam4.71048","title":"Associations of the Colon Tissue Microbiome and Circulating Bile Acids With Colorectal Adenoma Among Average‐Risk Women","abstract":"OBJECTIVE: The gut microbiome and bile acids (BAs) likely influence colorectal cancer (CRC) development and disparities. We conducted a nested case-control study of the associations of the colon tissue microbiome and circulating BAs with colorectal adenoma prevalence in the previously conducted multi-center Colorectal Neoplasia Screening with Colonoscopy in Average-Risk Women Regional Navy/Army Medical Centers study (CONCeRN). METHODS: We individually matched 143 women with adenoma to 279 without adenoma. Using 16S rRNA gene sequencing, we assessed alpha and beta diversity, taxonomic abundance, and co-abundance groups (CAGs). Fasting serum was analyzed for 13 primary and secondary BAs. RESULTS: The presence of oral-originating Porphyromonas was positively associated with adenomas (odds ratio [OR] and 95% confidence interval [CI] = 2.50 [1.18, 5.30]; p = 0.02). Race and study center explained statistically significant percentages of variation in the beta diversity matrices. BAs were generally positively associated with adenomas, though these results were not statistically significant. DISCUSSION: Overall, our findings suggest the colon tissue microbiome may differ by race and geography, and that certain oral-originating bacteria may be positively associated with adenomas.","journal":"Cancer Medicine","year":2025,"id":536669,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9435,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":966711,"name":"Maria F. Gomez","orcid":"0000-0003-3041-8259","position":1,"is_corresponding":false},{"id":975946,"name":"Stephanie Hogue","orcid":"0000-0002-5677-3518","position":2,"is_corresponding":false},{"id":1422509,"name":"Jessica R. Burns","orcid":null,"position":3,"is_corresponding":false},{"id":1422510,"name":"Nate Smith","orcid":null,"position":4,"is_corresponding":false},{"id":241829,"name":"Joshua N. Sampson","orcid":"0000-0003-2875-3365","position":5,"is_corresponding":false},{"id":275427,"name":"Erikka Loftfield","orcid":"0000-0002-3573-8748","position":6,"is_corresponding":false},{"id":362373,"name":"Patricia G. Wolf","orcid":"0000-0003-4779-7910","position":7,"is_corresponding":false},{"id":69702,"name":"Yunhu Wan","orcid":"0000-0002-6556-0602","position":8,"is_corresponding":false},{"id":299179,"name":"Andrew Warner","orcid":"0000-0001-6023-1423","position":9,"is_corresponding":false},{"id":264024,"name":"Belynda Hicks","orcid":"0000-0001-8014-4888","position":10,"is_corresponding":false},{"id":448679,"name":"Casey Dagnall","orcid":"0000-0001-7334-4718","position":11,"is_corresponding":false},{"id":1421991,"name":"Kristine Jones","orcid":"0000-0002-4611-9838","position":12,"is_corresponding":false},{"id":370723,"name":"Youngchul Kim","orcid":"0000-0002-2307-0330","position":13,"is_corresponding":false},{"id":1421992,"name":"Jin Xu","orcid":"0000-0003-0586-6084","position":14,"is_corresponding":false},{"id":5285,"name":"Jianxin Shi","orcid":"0000-0001-8606-4707","position":15,"is_corresponding":false},{"id":95614,"name":"Rashmi Sinha","orcid":"0000-0002-2466-7462","position":16,"is_corresponding":false},{"id":95612,"name":"Emily Vogtmann","orcid":"0000-0003-1355-5593","position":17,"is_corresponding":false},{"id":322995,"name":"Doratha A. Byrd","orcid":"0000-0003-4275-7901","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:52:09.056872Z","pmid":"40937639","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}