{"doi":"10.1002/cam4.6396","title":"Interstitial lung abnormalities after hospitalization for COVID‐19 in patients with cancer: A prospective cohort study","abstract":"INTRODUCTION: Survivors of SARS-CoV-2 pneumonia often develop persistent respiratory symptom and interstitial lung abnormalities (ILAs) after infection. Risk factors for ILA development and duration of ILA persistence after SARS-CoV-2 infection are not well described in immunocompromised hosts, such as cancer patients. METHODS: We conducted a prospective cohort study of 95 patients at a major cancer center and 45 patients at a tertiary referral center. We collected clinical and radiographic data during the index hospitalization for COVID-19 pneumonia and measured pneumonia severity using a semi-quantitative radiographic score, the Radiologic Severity Index (RSI). Patients were evaluated in post-COVID-19 clinics at 3 and 6 months after discharge and underwent comprehensive pulmonary evaluations (symptom assessment, chest computed tomography, pulmonary function tests, 6-min walk test). The association of clinical and radiological factors with ILAs at 3 and 6 months post-discharge was measured using univariable and multivariable logistic regression. RESULTS: Sixty-six (70%) patients of cancer cohort had ILAs at 3 months, of whom 39 had persistent respiratory symptoms. Twenty-four (26%) patients had persistent ILA at 6 months after hospital discharge. In adjusted models, higher peak RSI at admission was associated with ILAs at 3 (OR 1.5 per 5-point increase, 95% CI 1.1-1.9) and 6 months (OR 1.3 per 5-point increase, 95% CI 1.1-1.6) post-discharge. Fibrotic ILAs (reticulation, traction bronchiectasis, and architectural distortion) were more common at 6 months post-discharge. CONCLUSIONS: Post-COVID-19 ILAs are common in cancer patients 3 months after hospital discharge, and peak RSI and older age are strong predictors of persistent ILAs.","journal":"Cancer Medicine","year":2023,"id":375349,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9233,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1137946,"name":"Christopher Bertini","orcid":null,"position":1,"is_corresponding":false},{"id":1137568,"name":"Isabel Mira‐Avendano","orcid":"0000-0001-9274-9008","position":2,"is_corresponding":false},{"id":545354,"name":"Maryam Kaous","orcid":null,"position":3,"is_corresponding":false},{"id":804351,"name":"Bela Patel","orcid":"0000-0001-5804-5226","position":4,"is_corresponding":false},{"id":371873,"name":"Saadia A. Faiz","orcid":"0000-0001-7284-3945","position":5,"is_corresponding":false},{"id":442451,"name":"Vickie R. Shannon","orcid":"0000-0002-5938-4841","position":6,"is_corresponding":false},{"id":1065683,"name":"Diwakar D. Balachandran","orcid":"0000-0002-7427-9388","position":7,"is_corresponding":false},{"id":544316,"name":"Lara Bashoura","orcid":"0000-0003-1126-4039","position":8,"is_corresponding":false},{"id":597237,"name":"Roberto Adachi","orcid":"0000-0002-0146-0768","position":9,"is_corresponding":false},{"id":297875,"name":"Scott E. Evans","orcid":"0000-0003-4503-0644","position":10,"is_corresponding":false},{"id":1137947,"name":"Burton Dickey","orcid":null,"position":11,"is_corresponding":false},{"id":288823,"name":"Carol C. Wu","orcid":"0000-0003-1005-0995","position":12,"is_corresponding":false},{"id":283074,"name":"Girish S. 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