{"doi":"10.1002/cam4.6187","title":"Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>In randomized trials in women with breast cancer, exercise has been shown to have beneficial effects on cancer‐related circulating biomarkers that may impact survival. Such studies are lacking for ovarian cancer.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This secondary analysis of a published randomized controlled trial examined the impact of a 6‐month exercise intervention versus attention‐control on change in prespecified circulating biomarkers (cancer antigen 125 (CA‐125), C‐reactive protein (CRP), insulin‐like growth factor‐1(IGF‐1), insulin and leptin) in a subset of participants who provided a fasting blood draw (<jats:italic>N</jats:italic> = 104/144) at enrollment and at 6 months. Change in biomarkers between study arms was compared using a linear mixed effects model analysis. An exploratory analysis of the exercise intervention versus attention‐control on all‐cause mortality included all (<jats:italic>N</jats:italic> = 144) participants. All statistical tests were two‐sided.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Participants included in the biomarker analysis were 57.0 ± 8.8 (mean ± SD) years old and 1.6 ± 0.9 years post‐diagnosis. Adherence to the exercise intervention was 176.4 ± 63.5 min/week. Post intervention IGF‐1 (group difference in change: −14.2 (−26.1 to −2.3) ng/mL (least squared means (95% CI))) and leptin (−8.9 (−16.5 to −1.4) ng/mL) were significantly reduced in the exercise group (<jats:italic>N</jats:italic> = 53) compared to those in attention‐control (<jats:italic>N</jats:italic> = 51). No group difference in change was seen for CA‐125 (<jats:italic>p</jats:italic> = 0.54), CRP (<jats:italic>p</jats:italic> = 0.95), or insulin (<jats:italic>p</jats:italic> = 0.37). With median follow‐up of 70 months [range 6.6–105.4 months], 50/144 (34.7%) (exercise group; 24/74 (32.4%) versus attention‐control group; 26/70 (37.1%)) participants died with no between group difference in overall survival (<jats:italic>p</jats:italic> = 0.99).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Further studies are needed to determine the clinical significance of exercise‐induced changes in cancer‐related circulating biomarkers in women with ovarian cancer.</jats:p></jats:sec>","journal":"Cancer Medicine","year":2023,"id":643902,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1675640,"name":"Fang‐yong Li","orcid":null,"position":1,"is_corresponding":false},{"id":404632,"name":"Yang Zhou","orcid":"0000-0003-4978-8460","position":2,"is_corresponding":false},{"id":971713,"name":"Linda Gottlieb","orcid":null,"position":3,"is_corresponding":false},{"id":305544,"name":"Lingeng Lu","orcid":"0000-0001-9871-0809","position":4,"is_corresponding":false},{"id":426710,"name":"Reed Mszar","orcid":"0000-0001-8152-8031","position":5,"is_corresponding":false},{"id":709310,"name":"Maura Harrigan","orcid":"0000-0003-1977-5124","position":6,"is_corresponding":false},{"id":273723,"name":"Jennifer A. Ligibel","orcid":"0000-0002-0633-3151","position":7,"is_corresponding":false},{"id":971263,"name":"Radhika Gogoi","orcid":"0000-0002-8556-829X","position":8,"is_corresponding":false},{"id":736345,"name":"Peter E. Schwartz","orcid":"0000-0001-8060-6018","position":9,"is_corresponding":false},{"id":6547,"name":"Harvey A. Risch","orcid":"0000-0001-5337-3941","position":10,"is_corresponding":false},{"id":1675645,"name":"Melinda L. Irwin","orcid":null,"position":11,"is_corresponding":false},{"id":709309,"name":"Brenda Cartmel","orcid":"0000-0002-4748-5143","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer","abstract":"<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>In randomized trials in women with breast cancer, exercise has been shown to have beneficial effects on cancer‐related circulating biomarkers that may impact survival. Such studies are lacking for ovarian cancer.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This secondary analysis of a published randomized controlled trial examined the impact of a 6‐month exercise intervention versus attention‐control on change in prespecified circulating biomarkers (cancer antigen 125 (CA‐125), C‐reactive protein (CRP), insulin‐like growth factor‐1(IGF‐1), insulin and leptin) in a subset of participants who provided a fasting blood draw (<jats:italic>N</jats:italic> = 104/144) at enrollment and at 6 months. Change in biomarkers between study arms was compared using a linear mixed effects model analysis. An exploratory analysis of the exercise intervention versus attention‐control on all‐cause mortality included all (<jats:italic>N</jats:italic> = 144) participants. All statistical tests were two‐sided.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Participants included in the biomarker analysis were 57.0 ± 8.8 (mean ± SD) years old and 1.6 ± 0.9 years post‐diagnosis. Adherence to the exercise intervention was 176.4 ± 63.5 min/week. Post intervention IGF‐1 (group difference in change: −14.2 (−26.1 to −2.3) ng/mL (least squared means (95% CI))) and leptin (−8.9 (−16.5 to −1.4) ng/mL) were significantly reduced in the exercise group (<jats:italic>N</jats:italic> = 53) compared to those in attention‐control (<jats:italic>N</jats:italic> = 51). No group difference in change was seen for CA‐125 (<jats:italic>p</jats:italic> = 0.54), CRP (<jats:italic>p</jats:italic> = 0.95), or insulin (<jats:italic>p</jats:italic> = 0.37). With median follow‐up of 70 months [range 6.6–105.4 months], 50/144 (34.7%) (exercise group; 24/74 (32.4%) versus attention‐control group; 26/70 (37.1%)) participants died with no between group difference in overall survival (<jats:italic>p</jats:italic> = 0.99).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Further studies are needed to determine the clinical significance of exercise‐induced changes in cancer‐related circulating biomarkers in women with ovarian cancer.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37269192","pmcid":"PMC10417064","openalex_id":"https://openalex.org/W4379197501","authors":[],"funders":[{"funder_name":"National Cancer Institute","grant_id":"5R01CA138556","title":null},{"funder_name":"National Cancer Institute","grant_id":"P30 CA016359","title":null},{"funder_name":"National Center for Advancing Translational Sciences","grant_id":"UL1TR000142","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA138556","title":null},{"funder_name":"National Institutes of Health","grant_id":"2P30CA016359-15","title":"COMPREHENSIVE CANCER CENTER"},{"funder_name":"National Institutes of Health","grant_id":"5UL1TR000142-08","title":"Yale University Clinical and Translational Science Award Program"},{"funder_name":"National Institutes of Health","grant_id":"5R01CA138556-03","title":"Impact of exercise on ovarian cancer prognosis"}],"total_grants":7,"fwci":1.2702,"citation_percentile":0.80820378,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6187","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.6187","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.6187","host_type":"publisher"},{"url":"https://doi.org/10.1002/cam4.6187","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37269192","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10417064","host_type":"repository"},{"url":"https://doaj.org/article/9247fade49ae4a74992c7607d8069abd","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10417064/pdf/CAM4-12-15492.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10417064","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10417064?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1002/cam4.6187","host_type":""}],"fields_of_study":["Cancer survivorship and care","Cancer Risks and Factors","Nutrition and Health in Aging","03 medical and health sciences","0302 clinical medicine","Humans","Female","Biomarkers, Tumor","Insulin-Like Growth Factor I","Leptin","Biomarkers","Breast Neoplasms","C-Reactive Protein","Ovarian Neoplasms","Insulin"],"mesh_terms":["Breast Neoplasms","C-Reactive Protein","Female","Humans","Insulin","Insulin-Like Growth Factor I","Ovarian Neoplasms","Biomarkers, Tumor","Biomarkers","Leptin"],"keywords":["Medicine","Randomized controlled trial","Breast cancer","Internal medicine","Biomarker","Cancer","Ovarian cancer","Leptin","Insulin","Oncology","Obesity","Ovarian neoplasms","Exercise","Survival analysis","Biomarkers","Neoplasms. 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