{"doi":"10.1002/btm2.10741","title":"Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform","abstract":"Tumor resistance to chemotherapy is a common cause of cancer recurrence in patients with head and neck squamous cell carcinoma. The goal of this study is to establish and characterize a chemoresistant laryngeal cancer cell model and test its potential utility for chemosensitizing therapy. At the genotypic level, RNA sequencing confirmed that the cells acquired putative resistance with upregulated docetaxel-resistant (DR) genes (e.g., TUBB3, CYP24A1) and signaling pathways (e.g., PI3K/mTOR, autophagy). For phenotypic analysis, DR cells were co-cultured with laryngeal fibroblasts in a 2-channel microfluidic chip that mimics a hypoxic tumor core in vivo. A drug sensitivity test with a chemosensitizer, metformin (MTF), was performed on the laryngeal tumor-on-a-chip. Compared to non-treated controls, MTF-primed cancer cells exhibit higher sensitivity to docetaxel (DTX), that is, cell death. Collectively, this resistance-acquired cell model displayed presumed genotypic and phenotypic profiles of chemoresistance providing a viable option for testing new therapeutic strategies for restoring tumor sensitivity to DTX.","journal":"Bioengineering & Translational Medicine","year":2025,"id":551288,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9157,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1447121,"name":"Meghana Munipalle","orcid":"0009-0007-6325-7005","position":1,"is_corresponding":false},{"id":824153,"name":"Alain Pacis","orcid":"0000-0003-4883-6176","position":2,"is_corresponding":false},{"id":892891,"name":"Nader Sadeghi","orcid":"0000-0002-3218-2668","position":3,"is_corresponding":false},{"id":841579,"name":"Maryam Tabrizian","orcid":"0000-0002-5050-4480","position":4,"is_corresponding":false},{"id":504399,"name":"Nicole Y. K. Li‐Jessen","orcid":"0000-0003-2963-4763","position":5,"is_corresponding":false},{"id":892889,"name":"Christian R. Moya‐Garcia","orcid":"0000-0002-0468-9509","position":0,"is_corresponding":true}],"reference_count":145,"raw_metadata":null,"created_at":"2026-07-19T02:54:25.065895Z","pmid":"40385549","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}