{"doi":"10.1002/btm2.10737","title":"Ultrasound‐mediated mechanical forces activate selective tumor cell apoptosis","abstract":"Recent studies show that tumor cells undergo apoptosis after mechanical stretching, which promotes normal cell growth. Since ultrasound can produce similar sub-cellular mechanical stresses on the nanoscale, here we test the effect of ultrasound-mediated mechanical forces on tumors and normal cell survival. Surprisingly, tumor cells undergo apoptosis through a calpain-dependent mitochondrial pathway that relies upon calcium entry through the mechanosensitive Piezo1 channels. This is a general property of all tumor cell lines tested irrespective of tissue origin, but normal cells are unaffected. In vivo, ultrasound treatment promotes tumor cell killing in a mouse model with invasive CT26 cancer cell subcutaneous tumors and in the chick chorioallantoic membrane (CAM) model with relatively minor damage to chick embryos. Further, patient-derived pancreatic tumor organoids are killed by ultrasound treatment. Because ultrasound-mediated mechanical forces cause apoptosis of tumor cells from many different tissues in different microenvironments, it may offer a safe, non-invasive approach to augment tumor treatments.","journal":"Bioengineering & Translational Medicine","year":2024,"id":427209,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":555378,"name":"Felix Margadant","orcid":"0000-0002-6729-6155","position":1,"is_corresponding":false},{"id":1227905,"name":"Nehal Dwivedi","orcid":null,"position":2,"is_corresponding":false},{"id":1227906,"name":"Leslie K. Morgan","orcid":null,"position":3,"is_corresponding":false},{"id":555379,"name":"Mingxi Yao","orcid":"0000-0002-3905-8475","position":4,"is_corresponding":false},{"id":556455,"name":"Anushya Hariharan","orcid":null,"position":5,"is_corresponding":false},{"id":555380,"name":"Claire Alexandra Zhen Chew","orcid":"0000-0002-4435-6127","position":6,"is_corresponding":false},{"id":236124,"name":"Simon N. Powell","orcid":"0000-0002-8183-4765","position":7,"is_corresponding":false},{"id":500463,"name":"Glenn Kunnath Bonney","orcid":"0000-0002-9034-3255","position":8,"is_corresponding":false},{"id":555381,"name":"Michael P. Sheetz","orcid":"0000-0001-8747-3430","position":9,"is_corresponding":false},{"id":555377,"name":"Ajay Tijore","orcid":"0000-0002-0803-2168","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"40060768","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}