{"doi":"10.1002/btm2.10573","title":"An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma","abstract":"The cytokine interleukin (IL)-11 has been shown to play a role in promoting fibrosis and cancer, including lung adenocarcinoma, garnering interest as an attractive target for therapeutic intervention. We used combinatorial methods to engineer an IL-11 variant that binds with higher affinity to the IL-11 receptor and stimulates enhanced receptor-mediated cell signaling. Introduction of two additional point mutations ablates IL-11 ligand/receptor association with the gp130 coreceptor signaling complex, resulting in a high-affinity receptor antagonist. Unlike wild-type IL-11, this engineered variant potently blocks IL-11-mediated cell signaling and slows tumor growth in a mouse model of lung cancer. Our approach highlights a strategy where native ligands can be engineered and exploited to create potent receptor antagonists.","journal":"Bioengineering & Translational Medicine","year":2023,"id":367182,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":65353,"name":"Griffin G. Hartmann","orcid":"0000-0001-9213-8995","position":1,"is_corresponding":false},{"id":703805,"name":"Sean A. Yamada‐Hunter","orcid":"0000-0002-4372-6587","position":2,"is_corresponding":false},{"id":470941,"name":"Phillip Liu","orcid":"0000-0002-7935-7912","position":3,"is_corresponding":false},{"id":1124808,"name":"Camille F. Williams","orcid":null,"position":4,"is_corresponding":false},{"id":29971,"name":"Julien Sage","orcid":"0000-0002-8928-9968","position":5,"is_corresponding":false},{"id":226837,"name":"Jennifer R. Cochran","orcid":"0000-0002-6532-9873","position":6,"is_corresponding":false},{"id":614864,"name":"Brianna J. McIntosh","orcid":"0000-0003-3626-625X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-19T01:15:12.215513Z","pmid":"38023717","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}