{"doi":"10.1002/btm2.10309","title":"Immune‐responsive biodegradable scaffolds for enhancing neutrophil regeneration","abstract":"Neutrophils are essential effector cells for mediating rapid host defense and their insufficiency arising from therapy-induced side-effects, termed neutropenia, can lead to immunodeficiency-associated complications. In autologous hematopoietic stem cell transplantation (HSCT), neutropenia is a complication that limits therapeutic efficacy. Here, we report the development and in vivo evaluation of an injectable, biodegradable hyaluronic acid (HA)-based scaffold, termed HA cryogel, with myeloid responsive degradation behavior. In mouse models of immune deficiency, we show that the infiltration of functional myeloid-lineage cells, specifically neutrophils, is essential to mediate HA cryogel degradation. Post-HSCT neutropenia in recipient mice delayed degradation of HA cryogels by up to 3 weeks. We harnessed the neutrophil-responsive degradation to sustain the release of granulocyte colony stimulating factor (G-CSF) from HA cryogels. Sustained release of G-CSF from HA cryogels enhanced post-HSCT neutrophil recovery, comparable to pegylated G-CSF, which, in turn, accelerated cryogel degradation. HA cryogels are a potential approach for enhancing neutrophils and concurrently assessing immune recovery in neutropenic hosts.","journal":"Bioengineering & Translational Medicine","year":2022,"id":275120,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":476732,"name":"David A. McBride","orcid":"0000-0001-7695-5178","position":1,"is_corresponding":false},{"id":888155,"name":"W. T. Johnson","orcid":"0000-0002-0810-6454","position":2,"is_corresponding":false},{"id":476733,"name":"Arun K. Chumber","orcid":"0009-0004-8247-437X","position":3,"is_corresponding":false},{"id":253886,"name":"Alexander J. Najibi","orcid":"0000-0001-7761-392X","position":4,"is_corresponding":false},{"id":246171,"name":"Bo Ri Seo","orcid":"0000-0002-0871-015X","position":5,"is_corresponding":false},{"id":461173,"name":"Alexander Stafford","orcid":"0000-0003-4739-8346","position":6,"is_corresponding":false},{"id":2694,"name":"David T. Scadden","orcid":"0000-0001-9821-7133","position":7,"is_corresponding":false},{"id":65893,"name":"David Mooney","orcid":"0000-0001-6299-1194","position":8,"is_corresponding":false},{"id":269956,"name":"Nisarg J. Shah","orcid":"0000-0003-1727-5732","position":9,"is_corresponding":false},{"id":477946,"name":"Matthew D. Kerr","orcid":null,"position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:28:16.928746Z","pmid":"36684088","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}