{"doi":"10.1002/bsa3.70045","title":"Higher neighborhood deprivation is associated with accelerated disease progression in behavioral‐variant frontotemporal degeneration","abstract":"Abstract INTRODUCTION Neighborhood deprivation is associated with shorter survival, cognitive impairment, and neurodegeneration in aging and Alzheimer's disease. However, the association of neighborhood deprivation with disease progression in behavioral‐variant frontotemporal degeneration (bvFTD) is unknown. METHODS We examined associations between tertiles of neighborhood deprivation, using the Area Deprivation Index (ADI), and survival in 311 individuals clinically diagnosed with bvFTD from the Penn FTD Center. In a subset ( n = 161) with complete baseline data across measures of global cognition, executive function, and language, we examined the association of ADI with longitudinal change. RESULTS Compared to adults living in the least deprived neighborhoods, those living in the most deprived neighborhoods showed shorter survival after symptom onset and faster decline in global cognition, executive and language functions, independent of genetic risk. DISCUSSION Living in more deprived neighborhoods was associated with an accelerated disease course in bvFTD, highlighting an important socioeconomic disparity in disease prognosis. CLINICAL TRIAL REGISTRATION INFORMATION N/A","journal":"Alzheimer s & Dementia Behavior & Socioeconomics of Aging","year":2025,"id":580998,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":574942,"name":"Nadia Dehghani","orcid":"0000-0002-0385-7267","position":1,"is_corresponding":false},{"id":1107045,"name":"Sheina Emrani","orcid":null,"position":2,"is_corresponding":false},{"id":1492036,"name":"Anil R. Wadhwani","orcid":"0000-0002-7007-2371","position":3,"is_corresponding":false},{"id":371332,"name":"Melanie A. Matyi","orcid":"0000-0002-4623-2080","position":4,"is_corresponding":false},{"id":750910,"name":"Katheryn A Q Cousins","orcid":"0000-0003-1879-2766","position":5,"is_corresponding":false},{"id":301453,"name":"Emma Rhodes","orcid":"0000-0002-9053-0114","position":6,"is_corresponding":false},{"id":817021,"name":"Sacha B. Nelson","orcid":"0000-0002-0108-8599","position":7,"is_corresponding":false},{"id":843599,"name":"Shana D. Stites","orcid":"0000-0003-3994-4343","position":8,"is_corresponding":false},{"id":227428,"name":"Sharon X. Xie","orcid":"0000-0002-7886-4103","position":9,"is_corresponding":false},{"id":990235,"name":"Laynie Dratch","orcid":"0000-0002-2179-3199","position":10,"is_corresponding":false},{"id":679306,"name":"Vivianna M Van Deerlin","orcid":null,"position":11,"is_corresponding":false},{"id":767935,"name":"Allison Snyder","orcid":"0000-0002-1857-928X","position":12,"is_corresponding":false},{"id":227417,"name":"David J. Irwin","orcid":"0000-0002-5599-5098","position":13,"is_corresponding":false},{"id":227422,"name":"Corey T. McMillan","orcid":"0000-0002-7581-6405","position":14,"is_corresponding":false},{"id":260095,"name":"Lauren Massimo","orcid":"0000-0002-3407-7335","position":15,"is_corresponding":false},{"id":815607,"name":"Rory Boyle","orcid":"0000-0003-0787-6892","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:58:43.046112Z","pmid":"41346478","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}