{"doi":"10.1002/bjs.1800840725","title":"Genetic instability in patients with metachronous colorectal cancers","abstract":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Background</jats:title>\n                  <jats:p>Nearly 7 per cent of patients who undergo resection for colorectal cancer develop metachronous cancers several years later. A molecular marker that could identify patients susceptible to metachronous cancers would be of clinical importance.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Twenty-four colorectal cancers from 15 individuals with metachronous colorectal cancer were investigated for microsatellite instability at five loci by single stranded conformational polymorphism analysis. A control group of 14 colorectal cancers from individuals who had only developed one sporadic colorectal cancer each was analysed similarly.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>Microsatellite instability was demonstrated in 17 of 24 cancers from individuals with metachronous cancer compared with one of 14 cancers from individuals with a single colorectal cancer.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion</jats:title>\n                  <jats:p>These results suggest that testing for microsatellite instability may be useful in recognizing patients at high risk of developing metachronous colorectal cancers.</jats:p>\n               </jats:sec>","journal":"Journal of British 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factors in colorectal cancer","Multiple and Secondary Primary Cancers","Colorectal Cancer Treatments and Studies","Medicine","Aged","Aged, 80 and over","Colorectal Neoplasms","DNA, Neoplasm","Female","Genetic Predisposition to Disease","Humans","Male","Microsatellite Repeats","Middle Aged","Neoplasms, Second Primary","Polymerase Chain Reaction","Polymorphism, Single-Stranded Conformational"],"mesh_terms":["Aged","Aged, 80 and over","DNA, Neoplasm","Female","Humans","Male","Middle Aged","Colorectal Neoplasms","Polymerase Chain Reaction","Neoplasms, Second Primary","Polymorphism, Single-Stranded Conformational","Microsatellite Repeats","Genetic Predisposition to Disease"],"keywords":["Medicine","Colorectal cancer","Microsatellite instability","Oncology","Internal 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