{"doi":"10.1002/bit.28824","title":"Polymer scaffolds delineate healthy from diseased states at sites distal from the pancreas in two models of type 1 diabetes","abstract":"Type 1 diabetes (T1D) prevention is currently limited by the lack of diagnostic tools able to identify disease before autoimmune destruction of the pancreatic β cells. Autoantibody tests are used to predict risk and, in combination with glucose dysregulation indicative of β cell loss, to determine administration of immunotherapies. Our objective was to remotely identify immune changes associated with the disease, and we have employed a subcutaneously implanted microporous poly(e-caprolactone) (PCL) scaffold to function as an immunological niche (IN) in two models of T1D. Biopsy and analysis of the IN enables disease monitoring using transcriptomic changes at a distal site from autoimmune destruction of the pancreas, thereby gaining cellular level information about disease without the need for a biopsy of the native organ. Using this approach, we identified gene signatures that stratify healthy and diseased mice in both an adoptive transfer model and a spontaneous onset model of T1D. The gene signatures identified herein demonstrate the ability of the IN to identify immune activation associated with diabetes across models.","journal":"Biotechnology and Bioengineering","year":2024,"id":452274,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":437526,"name":"Russell Urie","orcid":"0000-0002-2728-2541","position":1,"is_corresponding":false},{"id":369753,"name":"Aaron H. Morris","orcid":"0000-0002-4680-2493","position":2,"is_corresponding":false},{"id":701606,"name":"Laila M. Rad","orcid":"0000-0001-7965-7272","position":3,"is_corresponding":false},{"id":776061,"name":"Elizabeth Bealer","orcid":"0000-0001-6767-4091","position":4,"is_corresponding":false},{"id":343637,"name":"Tadas Kasputis","orcid":null,"position":5,"is_corresponding":false},{"id":260792,"name":"Lonnie D. Shea","orcid":"0000-0002-9296-9673","position":6,"is_corresponding":false},{"id":417527,"name":"Jessica King","orcid":"0000-0002-2642-5977","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:02:50.407779Z","pmid":"39082734","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}