{"doi":"10.1002/bit.27529","title":"Metabolically engineered <i>Caldicellulosiruptor bescii</i> as a platform for producing acetone and hydrogen from lignocellulose","abstract":"Abstract The production of volatile industrial chemicals utilizing metabolically engineered extreme thermophiles offers the potential for processes with simultaneous fermentation and product separation. An excellent target chemical for such a process is acetone ( T b = 56°C), ideally produced from lignocellulosic biomass. Caldicellulosiruptor bescii ( T opt 78°C), an extremely thermophilic fermentative bacterium naturally capable of deconstructing and fermenting lignocellulose, was metabolically engineered to produce acetone. When the acetone pathway construct was integrated into a parent strain containing the bifunctional alcohol dehydrogenase from Clostridium thermocellum , acetone was produced at 9.1 mM (0.53 g/L), in addition to minimal ethanol 3.3 mM (0.15 g/L), along with net acetate consumption. This demonstrates that C. bescii can be engineered with balanced pathways in which renewable carbohydrate sources are converted to useful metabolites, primarily acetone and H 2 , without net production of its native fermentation products, acetate and lactate.","journal":"Biotechnology and Bioengineering","year":2020,"id":99341,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":488905,"name":"Ryan G. Bing","orcid":"0000-0003-1408-6469","position":1,"is_corresponding":false},{"id":488906,"name":"Jonathan K. Otten","orcid":"0000-0003-1298-0539","position":2,"is_corresponding":false},{"id":488907,"name":"Lisa M. Keller","orcid":"0000-0002-1194-1856","position":3,"is_corresponding":false},{"id":488908,"name":"Benjamin Zeldes","orcid":"0000-0003-2039-2446","position":4,"is_corresponding":false},{"id":488909,"name":"Michael W. W. Adams","orcid":"0000-0002-9796-5014","position":5,"is_corresponding":false},{"id":319733,"name":"Robert M. Kelly","orcid":"0000-0002-0639-3592","position":6,"is_corresponding":false},{"id":488904,"name":"Christopher T. Straub","orcid":"0000-0001-5579-7529","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T22:37:35.547042Z","pmid":"32770740","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}