{"doi":"10.1002/bit.260371111","title":"Tubular bioreactors: Case study of bioreactor performance for industrial production and scientific research","abstract":"<jats:title>Abstract</jats:title><jats:p>Application of bioreactors is dominated by industrial production with the consequence that bioreactors also for scientific purposes are mainly used following an empiric pragmatic approach. For the sake of a breakthrough in biotechnology in general, and especially for advanced process development, a more systematic approach is emphasized here. This methodology in bioreactor performance studies is explained and the meaning clarified in a case study of a new type of tubular bioreactor. The central role of so‐called “model bioreactors” in bench‐scale applications is illustrated as a powerful contribution to the optimal design of bioreactors in technical scale. Pilot plant data in case of a tubular reactor for the production of ethanol with <jats:italic>Zymomonas</jats:italic> and biopesticides with <jats:italic>Bacillus thuringiensis</jats:italic> are presented.</jats:p>","journal":"Biotechnology and Bioengineering","year":1991,"id":21904,"datarank":1.7529649476955174,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":1.258589417794868,"self_endowment_contribution":0.4943755299006494,"citer_contribution":1.258589417794868,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":23,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":139395,"name":"A. Moser","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18597337","pmcid":null,"openalex_id":"https://openalex.org/W2092409665","authors":[],"funders":[],"total_grants":0,"fwci":0.4252,"citation_percentile":0.6020282,"influential_citations":0,"citation_trend":[{"year":2015,"count":2},{"year":2018,"count":3},{"year":2019,"count":1},{"year":2021,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbit.260371111","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/bit.260371111","host_type":"publisher"},{"url":"https://doi.org/10.1002/bit.260371111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18597337","host_type":"repository"}],"fields_of_study":["Viral Infectious Diseases and Gene Expression in Insects","Biofuel production and bioconversion","Microbial Metabolic Engineering and Bioproduction","Medicine","Engineering","Environmental Science"],"mesh_terms":[],"keywords":["Bioreactor","Biochemical engineering","Biotechnology","Zymomonas mobilis","Process development","Process engineering","SCALE-UP","Biology","Engineering","Ethanol fuel","Biofuel","Botany","Physics"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Industry, innovation and infrastructure"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T17:12:26.051636Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}