{"doi":"10.1002/biot.201800039","title":"Heat Shock Protein Reports on Proteome Stress","abstract":"<jats:sec><jats:label/><jats:p>Proper regulation of protein homeostasis (proteostasis) is essential to maintain cellular fitness. Proteome stress causes imbalance of the proteostasis, leading to various diseases represented by neurodegenerative diseases, cancers, and metabolic disorders. The biosensor community recently embarked on the development of proteome stress sensors to report on the integrity of proteostasis in live cells. While most of these sensors are based on metastable mutants of specific client proteins, a recent sensor takes advantage of the specific association of heat shock protein 27 with protein aggregates and exhibits a diffusive to punctate fluorescent change in cells that are subjected to stress conditions. Thus, heat shock proteins can be also used as a family of sensors to monitor proteome stress.</jats:p></jats:sec>","journal":"Biotechnology Journal","year":2018,"id":22680,"datarank":0.5110815231816683,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.1814978365812353,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.1814978365812353,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":89441,"name":"Xin Zhang","orcid":"0000-0001-5113-1420","position":1,"is_corresponding":false},{"id":57694,"name":"Yu Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29461669","pmcid":null,"openalex_id":"https://openalex.org/W2790312732","authors":[],"funders":[{"funder_name":"Burroughs Wellcome FundCareer Award at the Scientific Interface","grant_id":"","title":null},{"funder_name":"Paul Berg Early Career Professorship","grant_id":"","title":null},{"funder_name":"Lloyd and Dottie Huck Early Career Award","grant_id":"","title":null}],"total_grants":3,"fwci":0.4638,"citation_percentile":0.62386814,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.201800039","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.201800039","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/biot.201800039","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbiot.201800039","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/biot.201800039","host_type":"publisher"},{"url":"https://doi.org/10.1002/biot.201800039","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29461669","host_type":"repository"}],"fields_of_study":["Heat shock proteins research","Endoplasmic Reticulum Stress and Disease","Protein Structure and Dynamics","Chemistry","Medicine","Biology","Animals","Biosensing Techniques","Heat-Shock Proteins","Humans","Mutation","Protein Aggregates","Protein Folding","Proteome","Proteostasis","Stress, Physiological"],"mesh_terms":["Proteostasis","Animals","Heat-Shock Proteins","Humans","Mutation","Stress, Physiological","Biosensing Techniques","Protein Folding","Proteome","Protein Aggregates"],"keywords":["Proteostasis","Proteome","Heat shock protein","HSF1","Biology","Cell biology","Unfolded protein response","Protein aggregation","Heat shock","Shock (circulatory)","Protein folding","Bioinformatics","Hsp70","Biochemistry","Endoplasmic reticulum","Medicine","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T15:19:22.679167Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}