{"doi":"10.1002/bies.201800078","title":"Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals","abstract":"<jats:sec><jats:label/><jats:p>Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general transcriptional machinery. Over the years, more chromatin‐binding modes have been discovered suggesting direct interaction of histone acetyltransferases and their protein complex partners with histone proteins. While much progress has been made in characterizing histone acetyltransferase complexes biochemically, cell‐free activity assay results are often at odds with in‐cell histone acetyltransferase activities. In‐cell studies suggest specific histone lysine targets, but broad recruitment modes, apparently not relying on specific DNA sequences, but on chromatin of a specific functional state. Here we review the evidence for general versus specific roles of individual nuclear lysine acetyltransferases in light of in vivo and in vitro data in the mammalian system.</jats:p></jats:sec>","journal":"BioEssays","year":2018,"id":688518,"datarank":0.7495818410646173,"base_score":4.997212273764115,"endowment":4.997212273764115,"self_citation_contribution":0.7495818410646173,"citation_network_contribution":0.0,"self_endowment_contribution":0.7495818410646173,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":147,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":431680,"name":"Tim Thomas","orcid":"0000-0002-7623-8344","position":1,"is_corresponding":false},{"id":431681,"name":"Anne K. Voss","orcid":"0000-0002-3853-9381","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Histone Lysine and Genomic Targets of Histone Acetyltransferases in Mammals","abstract":"<jats:sec><jats:label/><jats:p>Histone acetylation has been recognized as an important post‐translational modification of core nucleosomal histones that changes access to the chromatin to allow gene transcription, DNA replication, and repair. Histone acetyltransferases were initially identified as co‐activators that link DNA‐binding transcription factors to the general transcriptional machinery. Over the years, more chromatin‐binding modes have been discovered suggesting direct interaction of histone acetyltransferases and their protein complex partners with histone proteins. While much progress has been made in characterizing histone acetyltransferase complexes biochemically, cell‐free activity assay results are often at odds with in‐cell histone acetyltransferase activities. In‐cell studies suggest specific histone lysine targets, but broad recruitment modes, apparently not relying on specific DNA sequences, but on chromatin of a specific functional state. Here we review the evidence for general versus specific roles of individual nuclear lysine acetyltransferases in light of in vivo and in vitro data in the mammalian system.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":4.997212273764115,"endowment":4.997212273764115,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30144132","pmcid":null,"openalex_id":"https://openalex.org/W2888481448","authors":[],"funders":[{"funder_name":"National Health and Medical Research Council","grant_id":"1081421","title":"NHMRC Research Fellowship"},{"funder_name":"National Health and Medical Research Council","grant_id":"575512","title":"Uncoupled Research Fellowship"},{"funder_name":"National Health and Medical Research Council","grant_id":"1030704","title":"The role of Moz, an epigenetic regulator, in the pathogenesis of leukaemia"},{"funder_name":"National Health and Medical Research Council","grant_id":"1080146","title":"Unique and selective small molecules to dissect histone acetyltransferase biology"},{"funder_name":"National Health and Medical Research Council","grant_id":"1084248","title":"Regulation of haematopoietic stem cells through histone modifications"},{"funder_name":"National Health and Medical Research Council","grant_id":"1084352","title":"Chromatin regulation of neural stem cell multipotency"},{"funder_name":"National Health and Medical Research Council","grant_id":"1084504","title":"TAF8 is a suppressor of cell death"},{"funder_name":"National Health and Medical Research Council","grant_id":"1084509","title":"MOZ regulates cellular senescence"},{"funder_name":"National Health and Medical Research Council","grant_id":"1003435","title":"Genetic regulation of mammlian development"}],"total_grants":9,"fwci":4.2,"citation_percentile":0.95553415,"influential_citations":0,"citation_trend":[{"year":2019,"count":13},{"year":2020,"count":17},{"year":2021,"count":21},{"year":2022,"count":17},{"year":2023,"count":15},{"year":2024,"count":35},{"year":2025,"count":15},{"year":2026,"count":14}],"oa_status":"closed","license":"Wiley Online Library User Agreement","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbies.201800078","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.201800078","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/bies.201800078","host_type":"publisher"},{"url":"https://doi.org/10.1002/bies.201800078","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30144132","host_type":"repository"},{"url":"http://hdl.handle.net/11343/284407","host_type":"repository"},{"url":"http://minerva-access.unimelb.edu.au/bitstream/11343/284407/1/https%20rss.onlinelibrary.wiley.com%20doi%20am-pdf%2010.1002%20bies.pdf","host_type":""},{"url":"https://dx.doi.org/10.1002/bies.201800078","host_type":""},{"url":"https://doi.org/https://doi.org/10.1002/bies.201800078","host_type":""}],"fields_of_study":["Histone Deacetylase Inhibitors Research","Genomics and Chromatin Dynamics","Epigenetics and DNA Methylation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Acetylation","Animals","Chromatin","Gene Deletion","Genome","Histone Acetyltransferases","Histones","Humans","Lysine","Lysine Acetyltransferases","Mammals","Nuclear Proteins","Protein Processing, Post-Translational","RNA, Small Interfering"],"mesh_terms":["Lysine Acetyltransferases","Acetylation","Animals","Chromatin","Histones","Humans","Lysine","Mammals","Nuclear Proteins","Protein Processing, Post-Translational","Genome","Gene Deletion","RNA, Small Interfering","Histone Acetyltransferases"],"keywords":["Histone Acetyltransferases","Histone code","Histone H2A","Histone methyltransferase","Histone acetyltransferase","Biology","Histone octamer","Histone","Histone methylation","Chromatin","Histone H1","Chromatin remodeling","Transcription coregulator","Cell biology","Genetics","DNA","Nucleosome","Gene expression","Gene","DNA methylation","Mammals","570","Genome","Lysine","610","Nuclear Proteins","Acetylation","Lysine Acetyltransferases","Histones","Animals","Humans","RNA, Small Interfering","Protein Processing, Post-Translational","Gene Deletion","CBP/P300","GCN5","HBO1","KAT6A","MOF","PCAF","TIP60"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":13,"sdg_label":"13. Climate action"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T17:02:56.523233Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}