{"doi":"10.1002/bies.201700067","title":"Why the missing heritability might not be in the DNA","abstract":null,"journal":"BioEssays","year":2017,"id":596094,"datarank":0.6238324625039509,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":0.0,"self_endowment_contribution":0.6238324625039509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1513937,"name":"Qiaoying Lu","orcid":null,"position":1,"is_corresponding":false},{"id":37209,"name":"Eva Jablonka","orcid":"0000-0002-4549-8063","position":2,"is_corresponding":false},{"id":1513936,"name":"Pierrick Bourrat","orcid":"0000-0002-4465-6015","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Why the missing heritability might not be in the DNA","abstract":"There are four major hypotheses (H1, H2, H3, and H4) as to the source of missing heritability. We propose that estimates obtained from GWAS underestimate heritability by not taking into account non-DNA (epigenetic) sources of heritability. Taking those factors into account (H4) should result in increased heritability estimates.","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28582595","pmcid":null,"openalex_id":"https://openalex.org/W2624535262","authors":[],"funders":[],"total_grants":0,"fwci":4.8058,"citation_percentile":0.95019006,"influential_citations":0,"citation_trend":[{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":9},{"year":2020,"count":6},{"year":2021,"count":11},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":3},{"year":2025,"count":1},{"year":2026,"count":10}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbies.201700067","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.201700067","host_type":"publisher"},{"url":"https://doi.org/10.1002/bies.201700067","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28582595","host_type":"repository"}],"fields_of_study":["Genetic Associations and Epidemiology","Genomics and Chromatin Dynamics","Epigenetics and DNA Methylation"],"mesh_terms":["DNA","Humans","Quantitative Trait, Heritable","Epigenesis, Genetic","Genome-Wide Association Study","Epigenomics"],"keywords":["Heritability","Missing heritability problem","Genome-wide association study","Biology","Genetics","Epigenetics","Statistics","Evolutionary biology","Mathematics","Gene","Genetic variants","Genotype","Single-nucleotide polymorphism"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T23:28:28.335773Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}