{"doi":"10.1002/bies.10350","title":"Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiont","abstract":"<jats:title>Abstract</jats:title><jats:p>The coevolution of humans with their intestinal microflora has resulted in cooperative relationships that have shaped the biology and the genomes of these symbiotic partners. <jats:italic>Bacteroides thetaiotaomicron</jats:italic> is one such bacterial symbiont that is a dominant member of the intestinal microbiota of humans and other mammals. The recent report of the genome sequence of <jats:italic>B. thetaiotaomicron</jats:italic><jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"#bib1\">1</jats:ext-link> is the first reported for an abundant Gram‐negative organism of the human colonic microbiota and, as such, provides the first glimpse on a genomic scale of the genetic arsenal used by a Gram‐negative symbiont to dominate in this ecosystem. The genome has revealed large expansions of many paralogous groups of genes that encode products essential to the organism's ability to successfully compete in this environment. Most noteable is the organism's abundant machinery for utilizing a large variety of complex polysaccharides as a source of carbon and energy. The proteome also reveals the organism's extensive ability to adapt and regulate expression of its genes in response to the changing ecosystem. These factors, as well as others highlighted below, suggest an incredibly flexible and adaptable organism that is exquisitely equipped to dominate in its challenging and competitive niche. BioEssays 25:926–929, 2003. © 2003 Wiley Periodicals, Inc.</jats:p>","journal":"BioEssays","year":2003,"id":649660,"datarank":0.7193685818395114,"base_score":4.795790545596741,"endowment":4.795790545596741,"self_citation_contribution":0.7193685818395114,"citation_network_contribution":0.0,"self_endowment_contribution":0.7193685818395114,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":120,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":868,"name":"Michael J. Coyne","orcid":"0000-0003-4107-2353","position":1,"is_corresponding":false},{"id":1219767,"name":"Laurie E. Comstock","orcid":"0009-0002-6368-8351","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiont","abstract":"<jats:title>Abstract</jats:title><jats:p>The coevolution of humans with their intestinal microflora has resulted in cooperative relationships that have shaped the biology and the genomes of these symbiotic partners. <jats:italic>Bacteroides thetaiotaomicron</jats:italic> is one such bacterial symbiont that is a dominant member of the intestinal microbiota of humans and other mammals. The recent report of the genome sequence of <jats:italic>B. thetaiotaomicron</jats:italic><jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"#bib1\">1</jats:ext-link> is the first reported for an abundant Gram‐negative organism of the human colonic microbiota and, as such, provides the first glimpse on a genomic scale of the genetic arsenal used by a Gram‐negative symbiont to dominate in this ecosystem. The genome has revealed large expansions of many paralogous groups of genes that encode products essential to the organism's ability to successfully compete in this environment. Most noteable is the organism's abundant machinery for utilizing a large variety of complex polysaccharides as a source of carbon and energy. The proteome also reveals the organism's extensive ability to adapt and regulate expression of its genes in response to the changing ecosystem. These factors, as well as others highlighted below, suggest an incredibly flexible and adaptable organism that is exquisitely equipped to dominate in its challenging and competitive niche. BioEssays 25:926–929, 2003. © 2003 Wiley Periodicals, Inc.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14505359","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbies.10350","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/bies.10350","host_type":"publisher"}],"fields_of_study":["Bacteroides","Colon","Gene Expression Regulation","Humans","Hydrolysis","Models, Biological","Models, Genetic","Open Reading Frames","Polysaccharides","Symbiosis"],"mesh_terms":["Colon","Humans","Bacteroides","Polysaccharides","Symbiosis","Gene Expression Regulation","Hydrolysis","Open Reading Frames","Models, Biological","Models, Genetic"],"keywords":[],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.13634250.v1","title":"Additional file 3 of Seasonal shifts in the gut microbiome indicate plastic responses to diet in wild geladas","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.13634250","title":"Additional file 3 of Seasonal shifts in the gut microbiome indicate plastic responses to diet in wild geladas","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.15253497.v1","title":"Additional file 1 of Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.15253497","title":"Additional file 1 of Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26572309.v1","title":"Additional file 1 of Fine-scale spatial variation shape fecal microbiome diversity and composition in black-tailed prairie dogs (Cynomys ludovicianus)","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26572309","title":"Additional file 1 of Fine-scale spatial variation shape fecal microbiome diversity and composition in black-tailed prairie dogs (Cynomys ludovicianus)","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:06:36.750259Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}