{"doi":"10.1002/bdr2.2424","title":"Observed Prevalence of Congenital Situs Inversus in the United States Before and During the <scp>SARS</scp>‐<scp>CoV</scp>‐2 Pandemic, 2017–2022","abstract":"BACKGROUND: Reports from China describe an increase in the frequency of fetal situs inversus in 2023 after the country's \"zero-Covid\" policy was lifted, suggesting an association with maternal SARS-CoV-2 infection. However, a report of birth defects surveillance data from Scandinavia observed no sustained increase during the SARS-CoV-2 pandemic (2020-2022 vs. 2018-2019). We examined birth defects surveillance data to assess any increase in situs inversus in the U.S. during the SARS-CoV-2 pandemic. METHODS: We combined data from four population-based birth defects programs in Massachusetts, Minnesota, North Carolina, and Atlanta, Georgia, to compare the prevalence of situs inversus among infants and fetuses delivered before (2017-2019) and during (2021-2022) the SARS-CoV-2 pandemic. We defined situs inversus as mirror-image transposition of the heart and/or other organs, or primary ciliary dyskinesis with situs inversus, excluding isolated dextrocardia. The programs varied in the pregnancy outcomes included (live births ± non-live births); all included both prenatal and postnatal diagnoses. RESULTS: We identified 294 infants and fetuses with situs inversus (6.8% non-live births). We estimated the combined prevalence per 10,000 live births as 1.72 during the pandemic versus 1.71 before the pandemic (OR = 1.005; 95% CI: 0.778-1.297). The estimated annual prevalence ranged from 1.41 in 2017 to 2.21 in 2019 with no significant trend across the study period (p = 0.39). CONCLUSIONS: We did not observe an increase in situs inversus during the SARS-CoV-2 pandemic. Because information about SARS-CoV-2 infection among individual pregnancies was not available from all programs, we could not assess a specific association with maternal infection.","journal":"Birth Defects Research","year":2024,"id":452059,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9053,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1274354,"name":"Sook‐Ja Cho","orcid":null,"position":1,"is_corresponding":false},{"id":275139,"name":"Nina Forestieri","orcid":"0000-0001-7894-0279","position":2,"is_corresponding":false},{"id":1274355,"name":"Michele Hort","orcid":null,"position":3,"is_corresponding":false},{"id":493350,"name":"Eirini Nestoridi","orcid":null,"position":4,"is_corresponding":false},{"id":378227,"name":"Cynthia A. Moore","orcid":"0000-0003-4224-2692","position":5,"is_corresponding":false},{"id":492759,"name":"Erin B. Stallings","orcid":"0000-0002-0461-1410","position":6,"is_corresponding":false},{"id":1232629,"name":"Elizabeth B. Gray","orcid":"0000-0003-3111-3537","position":7,"is_corresponding":false},{"id":385369,"name":"Jennita Reefhuis","orcid":"0000-0002-4747-4831","position":8,"is_corresponding":false},{"id":268652,"name":"Janet D. Cragan","orcid":"0000-0002-6571-793X","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T02:02:50.407779Z","pmid":"39665216","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}