{"doi":"10.1002/bdr2.2250","title":"Is gastroschisis associated with county‐level socio‐environmental quality during pregnancy?","abstract":"BACKGROUND: Gastroschisis prevalence more than doubled between 1995 and 2012. While there are individual-level risk factors (e.g., young maternal age, low body mass index), the impact of environmental exposures is not well understood. METHODS: We used the U.S. Environmental Protection Agency's Environmental Quality Index (EQI) as a county-level estimate of cumulative environmental exposures for five domains (air, water, land, sociodemographic, and built) and overall from 2006 to 2010. Adjusted odds ratios (aOR) and 95% confidence interval (CI) were estimated from logistic regression models between EQI tertiles (better environmental quality (reference); mid; poorer) and gastroschisis in the National Birth Defects Prevention Study from births delivered between 2006 and 2011. Our analysis included 594 cases with gastroschisis and 4105 infants without a birth defect (controls). RESULTS: Overall EQI was modestly associated with gastroschisis (aOR [95% CI]: 1.29 [0.98, 1.71]) for maternal residence in counties with poorer environmental quality, compared to the reference (better environmental quality). Within domain-specific indices, only the sociodemographic domain (aOR: 1.51 [0.99, 2.29]) was modestly associated with gastroschisis, when comparing poorer to better environmental quality. CONCLUSIONS: Future work could elucidate pathway(s) by which components of the sociodemographic domain or possibly related psychosocial factors like chronic stress potentially contribute to risk of gastroschisis.","journal":"Birth Defects Research","year":2023,"id":412002,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9087,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1192939,"name":"Achal Patel","orcid":null,"position":1,"is_corresponding":false},{"id":796236,"name":"Christine L. Gray","orcid":"0000-0002-0751-1626","position":2,"is_corresponding":false},{"id":412358,"name":"Lynne C. Messer","orcid":"0000-0002-7332-6170","position":3,"is_corresponding":false},{"id":351918,"name":"Corinna Keeler","orcid":"0000-0002-3445-6589","position":4,"is_corresponding":false},{"id":375848,"name":"Peter H. Langlois","orcid":"0000-0001-6765-4963","position":5,"is_corresponding":false},{"id":385369,"name":"Jennita Reefhuis","orcid":"0000-0002-4747-4831","position":6,"is_corresponding":false},{"id":312581,"name":"Suzanne M. Gilboa","orcid":"0000-0001-7092-6667","position":7,"is_corresponding":false},{"id":379338,"name":"Martha M. Werler","orcid":"0000-0003-3392-6814","position":8,"is_corresponding":false},{"id":17736,"name":"Gary M. Shaw","orcid":"0000-0001-7438-4914","position":9,"is_corresponding":false},{"id":375804,"name":"Suzan L. Carmichael","orcid":"0000-0001-6310-5924","position":10,"is_corresponding":false},{"id":268673,"name":"Wendy N. Nembhard","orcid":"0000-0002-8318-4049","position":11,"is_corresponding":false},{"id":764526,"name":"Tabassum Z. Insaf","orcid":"0000-0003-4725-2515","position":12,"is_corresponding":false},{"id":268654,"name":"Marcia L. Feldkamp","orcid":"0000-0001-9171-7848","position":13,"is_corresponding":false},{"id":401676,"name":"Kristin M. Conway","orcid":"0000-0001-8633-966X","position":14,"is_corresponding":false},{"id":793263,"name":"Danelle T. Lobdell","orcid":"0000-0001-6457-5952","position":15,"is_corresponding":false},{"id":375847,"name":"Tania A. Desrosiers","orcid":"0000-0003-1600-3700","position":16,"is_corresponding":false},{"id":416767,"name":"the National Birth Defects Prevention Study","orcid":null,"position":17,"is_corresponding":false},{"id":793262,"name":"Alison K. Krajewski","orcid":"0000-0002-1916-5310","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:21:46.548301Z","pmid":"37772934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}