{"doi":"10.1002/bdd.2510040202","title":"Influence of concentration‐dependent protein binding on serum concentrations and urinary excretion of disopyramide and its metabolite following oral administration","abstract":"<jats:title>Abstract</jats:title><jats:p>Concentrations of disopyramide (D) and mono‐N‐dealkyldisopyramide (MND) were measured in serum and urine following administration of 100, 150, 200, and 300 mg D to four volunteers. The free fraction of D in serum was drug concentration‐dependent in all four subjects following the administration of the four doses. Areas under the free (unbound) D serum concentration‐time curves (AUC<jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/tex2gif-stack-1.gif\" xlink:title=\"urn:x-wiley:01422782:media:BDD2510040202:tex2gif-stack-1\" />) were linearly related to dose following 100–200 mg D. AUC<jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/tex2gif-stack-2.gif\" xlink:title=\"urn:x-wiley:01422782:media:BDD2510040202:tex2gif-stack-2\" /> values were 30–60 per cent higher than expected in two subjects following 300 mg D due to an apparent dose‐dependent decrease in D renal tubular secretion. Renal clearance of free D averaged 10·91h<jats:sup>−1</jats:sup>. The renal clearance of MND averaged 10·31h<jats:sup>−1</jats:sup>. The urinary excretion of MND was proportional to disopyramide dose.</jats:p>","journal":"Biopharmaceutics &amp; Drug Disposition","year":1983,"id":29185,"datarank":0.5595239110981065,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.21413614714899953,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.21413614714899953,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":150969,"name":"John J. Lima","orcid":null,"position":1,"is_corresponding":false},{"id":150970,"name":"David B. Haughey","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6882879","pmcid":null,"openalex_id":"https://openalex.org/W1988054067","authors":[],"funders":[],"total_grants":0,"fwci":1.2174,"citation_percentile":0.76728131,"influential_citations":0,"citation_trend":[{"year":2021,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fbdd.2510040202","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdd.2510040202","host_type":"publisher"},{"url":"https://doi.org/10.1002/bdd.2510040202","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6882879","host_type":"repository"}],"fields_of_study":["Thermoregulation and physiological responses","Electrolyte and hormonal disorders","Muscle metabolism and nutrition","Chemistry","Medicine","Administration, Oral","Blood Proteins","Disopyramide","Dose-Response Relationship, Drug","Humans","Metabolic Clearance Rate","Protein Binding","Pyridines"],"mesh_terms":["Administration, Oral","Blood Proteins","Disopyramide","Dose-Response Relationship, Drug","Humans","Metabolic Clearance Rate","Protein Binding","Pyridines"],"keywords":["Disopyramide","Metabolite","Urine","Free fraction","Pharmacokinetics","Chemistry","Excretion","Endocrinology","Serum concentration","Internal medicine","Renal function","Oral administration","Urinary system","Renal physiology","Volunteer","Pharmacology","Medicine","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T22:50:20.188393Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}