{"doi":"10.1002/asia.202200426","title":"A Cell Trappable Methyl Rhodol‐Based Fluorescent Probe for Hydrogen Sulfide Detection","abstract":"Abstract Hydrogen sulfide is a biologically important molecule and developing chemical tools that enable further investigations into the functions of H 2 S is essential. Fluorescent turn‐on H 2 S probes have been developed for use in cellulo and in vivo , but the membrane permeability of these probes can lead to probe leakage and signal attenuation over time. Here we report a cell trappable fluorescent probe for H 2 S, CT‐MeRhoAz , which is based on a methylrhodolazide scaffold derivatized with an acetoxymethyl ester group. Prior to ester cleavage, the CT‐MeRhoAz probe generates a 2500‐fold turn‐on response to H 2 S, which is enhanced to a 3000‐fold response for the carboxylic acid form of the probe. Additionally, the probe is highly selective for H 2 S over other biologically relevant sulfur, oxygen, and nitrogen‐based analytes. Live cell imaging experiments confirmed the biocompatibility of CT‐MeRhoAz and also that it is cell trappable, unlike the parent MeRhoAz scaffold.","journal":"Chemistry - An Asian Journal","year":2022,"id":268890,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9475,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":931617,"name":"Matthew D. Hammers","orcid":null,"position":1,"is_corresponding":false},{"id":931618,"name":"Mary S. Earp","orcid":null,"position":2,"is_corresponding":false},{"id":861005,"name":"Annie K. Gilbert","orcid":"0000-0002-1112-0089","position":3,"is_corresponding":false},{"id":325445,"name":"Michael D. Pluth","orcid":"0000-0003-3604-653X","position":4,"is_corresponding":false},{"id":931616,"name":"Kaylin G. Fosnacht","orcid":null,"position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T00:27:14.088663Z","pmid":"35696559","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}