{"doi":"10.1002/art.70026","title":"Per‐ and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative","abstract":"OBJECTIVE: To explore whether biologic levels of specific per- and polyfluoroalkyl substances (PFAS) and a mixture of PFAS-reflecting the overall effect and accounting for correlations among PFAS-relate to incident hand osteoarthritis (HOA) and progression. METHODS: Among a case-cohort sample from the Osteoarthritis Initiative (n = 1,878), we examined associations of eight PFAS in serum with odds of developing over the subsequent 4 years (1) symptomatic HOA and (2) an increased number of joints with radiographic osteoarthritis (Kellgren-Lawrence ≥2; yes/no). We used weighted logistic regression to assess single PFAS (continuous and quartiles) and quantile g-computation to assess the PFAS mixture in relation to our primary outcomes. RESULTS: ). Participants with higher perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA; continuous variables) had greater odds of incident symptomatic HOA (odds ratio [OR] [95% confidence interval (CI)] per interquartile range increment: PFDA 1.12 [1.05-1.20]; PFNA 1.07 [1.00-1.13]), but associations were not monotonic when these PFAS were represented in quartiles. Participants with higher perfluorohexane sulfonic acid had lower odds of incident HOA (eg, OR 0.94 [95% CI 0.88-1.00] per interquartile range increment). We observed no other consistent associations between PFAS and either outcome. CONCLUSION: We observed possible associations of PFDA and PFNA serum concentrations with symptomatic HOA incidence, but we otherwise found no consistent evidence that greater PFAS concentrations relate to a greater chance of developing HOA incidence or progression.","journal":"Arthritis & Rheumatology","year":2025,"id":537674,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8746,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":928512,"name":"Lisa B. Rokoff","orcid":"0000-0003-2147-0397","position":1,"is_corresponding":false},{"id":1129449,"name":"Bing Lu","orcid":"0000-0003-0179-6146","position":2,"is_corresponding":false},{"id":406186,"name":"Timothy E. McAlindon","orcid":"0000-0002-5031-1021","position":3,"is_corresponding":false},{"id":400203,"name":"Charles B. Eaton","orcid":"0000-0002-7723-9461","position":4,"is_corresponding":false},{"id":388384,"name":"Mary B. Roberts","orcid":"0000-0001-5509-5818","position":5,"is_corresponding":false},{"id":1424317,"name":"Diana Mathes","orcid":null,"position":6,"is_corresponding":false},{"id":1424318,"name":"Colleen Lestician","orcid":null,"position":7,"is_corresponding":false},{"id":1424319,"name":"Zhijin Carrie Xu","orcid":null,"position":8,"is_corresponding":false},{"id":1424320,"name":"Zhihua Tina Fan","orcid":null,"position":9,"is_corresponding":false},{"id":1424321,"name":"Shawn O'Leary","orcid":null,"position":10,"is_corresponding":false},{"id":394986,"name":"I.K. Haugen","orcid":"0000-0001-7810-2216","position":11,"is_corresponding":false},{"id":2818,"name":"Jérémie Sellam","orcid":"0000-0002-1814-6003","position":12,"is_corresponding":false},{"id":14799,"name":"Alice Courties","orcid":"0000-0001-8122-701X","position":13,"is_corresponding":false},{"id":254531,"name":"Abby F. Fleisch","orcid":"0000-0002-2789-6412","position":14,"is_corresponding":false},{"id":406187,"name":"Jeffrey B. Driban","orcid":"0000-0001-6098-4273","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:52:16.891390Z","pmid":"41429602","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}