{"doi":"10.1002/art.43272","title":"A Randomized, Double‐Blind, Placebo‐Controlled Trial of Abatacept for the Treatment of Relapsing, Nonsevere Granulomatosis With Polyangiitis","abstract":"OBJECTIVE: To compare the efficacy of abatacept to placebo for the treatment of relapsing, nonsevere granulomatosis with polyangiitis (GPA). METHODS: In this multicenter trial, eligible patients with relapsing, nonsevere GPA were randomized to receive abatacept 125 mg subcutaneously once a week or placebo, both together with prednisone 30 mg/day (or equivalent), tapered and discontinued at week 12. Patients already taking methotrexate, azathioprine, mycophenolate, or leflunomide continued this medication at a stable dose. Patients achieving remission remained on their randomized assignment until relapse, early termination, or the common close date 12 months after enrollment of the last patient. Those who had a nonsevere relapse, had nonsevere worsening, or were not in remission by month 6 had the option to receive open-label abatacept. The primary end point was the rate of treatment failure, defined as relapse, disease worsening, or failure to achieve a Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) of 0 or 1 by six months. RESULTS: Sixty-five patients were randomized; 34 received abatacept and 31 received placebo. No statistical difference in the treatment failure rate was found between those who received abatacept and those who received placebo (P = 0.853). Treatment with abatacept did not demonstrate any statistical difference from placebo in key secondary end points, including time to full remission (BVAS/WG = 0), duration of glucocorticoid-free remission, relapse severity, prevention of damage, and patient-reported quality-of-life outcomes. There was no difference in the frequency or severity of adverse events between treatment arms, including infection. CONCLUSION: In patients with relapsing, nonsevere GPA, abatacept did not reduce the risk of relapse, severe worsening, or failure to achieve remission.","journal":"Arthritis & Rheumatology","year":2025,"id":517499,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107973,"name":"Nader Khalidi","orcid":"0000-0002-8270-2617","position":1,"is_corresponding":false},{"id":615349,"name":"Jason Springer","orcid":"0000-0002-3903-6049","position":2,"is_corresponding":false},{"id":678744,"name":"Marcia Friedman","orcid":"0000-0001-6722-2159","position":3,"is_corresponding":false},{"id":1043067,"name":"Bernhard Hellmich","orcid":"0000-0002-8014-1801","position":4,"is_corresponding":false},{"id":251779,"name":"Christian Pagnoux","orcid":"0000-0001-6287-9549","position":5,"is_corresponding":false},{"id":697310,"name":"Natasha Dehghan","orcid":null,"position":6,"is_corresponding":false},{"id":253214,"name":"Ora Gewurz‐Singer","orcid":null,"position":7,"is_corresponding":false},{"id":251773,"name":"Curry L. Koening","orcid":"0000-0002-4494-7672","position":8,"is_corresponding":false},{"id":616929,"name":"Yih Chang Lin","orcid":null,"position":9,"is_corresponding":false},{"id":61593,"name":"Paul A. Monach","orcid":"0000-0003-4937-0515","position":10,"is_corresponding":false},{"id":27563,"name":"Larry W. Moreland","orcid":"0000-0003-4483-0359","position":11,"is_corresponding":false},{"id":1279650,"name":"Aurore Fifi‐Mah","orcid":"0000-0001-5417-9825","position":12,"is_corresponding":false},{"id":107974,"name":"Oliver Floßmann","orcid":"0000-0001-5976-3609","position":13,"is_corresponding":false},{"id":253213,"name":"Lindsy Forbess","orcid":null,"position":14,"is_corresponding":false},{"id":251776,"name":"Peter Lanyon","orcid":"0000-0002-9855-6802","position":15,"is_corresponding":false},{"id":1384439,"name":"Eamonn Molloy","orcid":null,"position":16,"is_corresponding":false},{"id":25214,"name":"Ulrich Specks","orcid":"0000-0002-6559-1206","position":17,"is_corresponding":false},{"id":251783,"name":"Robert Spiera","orcid":"0000-0003-2911-6800","position":18,"is_corresponding":false},{"id":1383811,"name":"Elaine Yacyshyn","orcid":"0000-0002-2753-2790","position":19,"is_corresponding":false},{"id":107989,"name":"Carol A. McAlear","orcid":"0000-0002-0016-6866","position":20,"is_corresponding":false},{"id":1383812,"name":"Cristina Burroughs","orcid":"0000-0002-0660-8127","position":21,"is_corresponding":false},{"id":251765,"name":"Rachel Jones","orcid":"0000-0003-4790-283X","position":22,"is_corresponding":false},{"id":251782,"name":"Rennie L. Rhee","orcid":"0000-0002-4907-0304","position":23,"is_corresponding":false},{"id":775004,"name":"Rula A. Hajj‐Ali","orcid":"0000-0001-6314-4827","position":24,"is_corresponding":false},{"id":314374,"name":"Kenneth J. Warrington","orcid":"0000-0001-7708-2487","position":25,"is_corresponding":false},{"id":328459,"name":"David Cuthbertson","orcid":"0000-0002-3785-9834","position":26,"is_corresponding":false},{"id":5970,"name":"Jeffrey P. Krischer","orcid":"0000-0003-4526-888X","position":27,"is_corresponding":false},{"id":25203,"name":"David Jayne","orcid":"0000-0002-1712-0637","position":28,"is_corresponding":false},{"id":5969,"name":"Peter A. Merkel","orcid":"0000-0001-9284-7345","position":29,"is_corresponding":false},{"id":251775,"name":"Carol A. Langford","orcid":"0000-0001-9498-321X","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"40506793","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}