{"doi":"10.1002/art.43027","title":"Weight Reduction and Target Serum Urate Level: A Longitudinal Study of Annual Medical Examination","abstract":"OBJECTIVE: Our objective was to evaluate associations of weight reduction with serum urate (SU) changes and achieving an SU level <6 mg/dL in the real-world setting, outside of specific weight reduction interventions. METHODS: We analyzed systematically collected data of annual medical examination participants from October 2012 to October 2022. Exposure was weight change (increase or decrease) between two consecutive visits, categorized as minimal (≤0.9 kg, reference), small (1.0-4.9 kg), moderate (5.0-9.9 kg), and large (≥10 kg). Outcomes included SU changes between two consecutive visits and achieving an SU level <6 mg/dL in participants with hyperuricemia (SU level ≥7 mg/dL at the previous visit). RESULTS: We identified 58,630 eligible participants (median age 46 years, 51.3% female, 19.4% with overweight, median SU level 5.3 mg/dL, and 5.6% with a history of gout and/or hyperuricemia) with 336,814 visits over a median of 5.3 years. After adjustment for relevant covariates, linear general estimating equations estimated mean SU changes based on observed weight reductions (vs minimal changes) were as follows: small, -0.10 mg/dL (95% confidence interval [CI] -0.10 to -0.09 mg/dL); moderate, -0.34 mg/dL (95% CI -0.36 to -0.32 mg/dL); and large, -0.64 (95% CI -0.70 to -0.58 mg/dL). In participants with hyperuricemia, adjusted relative risks for achieving an SU level <6 mg/dL by modified Poisson regression were 1.25 (95% CI 1.15-1.37) in small weight reductions, 2.82 (95% CI 2.43-3.27) in moderate weight reductions, and 5.27 (95% CI 4.15-6.70) in large weight reductions, with corresponding numbers needed to treat of 61.1 for small weight reductions, 8.5 for moderate weight reductions, and 3.6 for large weight reductions. CONCLUSION: Small weight reductions were associated with only small SU changes. Some participants with hyperuricemia can achieve the target SU level with moderate to large weight reductions.","journal":"Arthritis & Rheumatology","year":2024,"id":441309,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6741,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":498066,"name":"Masato Okada","orcid":"0000-0002-0357-0127","position":1,"is_corresponding":false},{"id":1239433,"name":"Tomohiro Shinozaki","orcid":"0000-0003-3395-9691","position":2,"is_corresponding":false},{"id":1253784,"name":"Takahiro Suzuki","orcid":"0000-0002-9768-0780","position":3,"is_corresponding":false},{"id":1239434,"name":"Takehiro Nakai","orcid":"0000-0003-0588-9518","position":4,"is_corresponding":false},{"id":1253785,"name":"Hiroki Ozawa","orcid":"0009-0002-4249-2376","position":5,"is_corresponding":false},{"id":1239435,"name":"Hiromichi Tamaki","orcid":"0009-0009-9620-9995","position":6,"is_corresponding":false},{"id":1239436,"name":"Mitsumasa Kishimoto","orcid":"0000-0002-4007-1589","position":7,"is_corresponding":false},{"id":1239437,"name":"Hiroshi Hasegawa","orcid":"0000-0003-1732-4207","position":8,"is_corresponding":false},{"id":1239941,"name":"Takeaki Matsuda","orcid":null,"position":9,"is_corresponding":false},{"id":608895,"name":"Javier Marrugo","orcid":"0000-0001-9157-4269","position":10,"is_corresponding":false},{"id":335237,"name":"Sara K. Tedeschi","orcid":"0000-0001-9475-1363","position":11,"is_corresponding":false},{"id":236763,"name":"Hyon K. Choi","orcid":"0000-0002-2862-0442","position":12,"is_corresponding":false},{"id":391215,"name":"Daniel H. Solomon","orcid":"0000-0001-8202-5428","position":13,"is_corresponding":false},{"id":1239432,"name":"Sho Fukui","orcid":"0000-0002-3082-1374","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:01:06.281460Z","pmid":"39400956","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}