{"doi":"10.1002/art.42649","title":"Relation of <scp>Intra‐Articular</scp> Mineralization to Knee Pain in Knee Osteoarthritis: A Longitudinal Analysis in the <scp>MOST</scp> Study","abstract":"OBJECTIVE: Intra-articular (IA) calcium crystal deposition is common in knee osteoarthritis (OA), but of unclear significance. It is possible that low-grade, crystal-related inflammation may contribute to knee pain. We examined the longitudinal relation of computed tomography (CT)-detected IA mineralization to the development of knee pain. METHODS: We used data from the National Institutes of Health-funded longitudinal Multicenter Osteoarthritis Study. Participants had knee radiographs and bilateral knee CTs at baseline, and pain assessments every 8 months for 2 years. CT images were scored using the Boston University Calcium Knee Score. We longitudinally examined the relation of CT-detected IA mineralization to the risk of frequent knee pain (FKP), intermittent or constant knee pain worsening, and pain severity worsening using generalized linear mixed-effects models. RESULTS: ). Overall, 10.2% of knees had IA mineralization. The presence of any IA mineralization in the cartilage was associated with 2.0 times higher odds of having FKP (95% confidence interval [CI] 1.38-2.78) and 1.86 times more frequent intermittent or constant pain (95% CI 1.20-2.78), with similar results seen for the presence of any IA mineralization in the meniscus or joint capsule. A higher burden of IA mineralization anywhere within the knee was associated with a higher odds of all pain outcomes (odds ratio ranged from 2.14 to 2.21). CONCLUSION: CT-detected IA mineralization was associated with risk of having more frequent, persistent, and worsening knee pain over 2 years. Targeting IA mineralization may have therapeutic potential for pain improvement in knee OA.","journal":"Arthritis & Rheumatology","year":2023,"id":335466,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7201,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":708528,"name":"Mohamed Jarraya","orcid":"0000-0002-8095-0174","position":1,"is_corresponding":false},{"id":313864,"name":"Ali Guermazi","orcid":"0000-0002-9374-8266","position":2,"is_corresponding":false},{"id":401965,"name":"J.A. Lynch","orcid":"0000-0003-3624-2741","position":3,"is_corresponding":false},{"id":331285,"name":"Na Wang","orcid":"0000-0002-4936-6244","position":4,"is_corresponding":false},{"id":765242,"name":"G. Rabasa","orcid":null,"position":5,"is_corresponding":false},{"id":267435,"name":"S. Reza Jafarzadeh","orcid":"0000-0002-1099-9175","position":6,"is_corresponding":false},{"id":50681,"name":"Michael C. Nevitt","orcid":"0000-0002-6988-7530","position":7,"is_corresponding":false},{"id":332065,"name":"James C. Torner","orcid":"0000-0003-0979-4874","position":8,"is_corresponding":false},{"id":245367,"name":"Cora E. Lewis","orcid":"0000-0002-2301-5796","position":9,"is_corresponding":false},{"id":31266,"name":"David T. Felson","orcid":"0000-0002-2668-2447","position":10,"is_corresponding":false},{"id":55625,"name":"Tuhina Neogi","orcid":"0000-0002-9515-1711","position":11,"is_corresponding":false},{"id":243079,"name":"Jean W. Liew","orcid":"0000-0002-8104-2450","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:09:58.338267Z","pmid":"37410792","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}