{"doi":"10.1002/art.42370","title":"Association of Antibodies to <i>Prevotella copri</i> in Anti–Cyclic Citrullinated <scp>Peptide‐Positive</scp> Individuals At Risk of Developing Rheumatoid Arthritis and in Patients With Early or Established Rheumatoid Arthritis","abstract":"OBJECTIVE: Prevotella copri (P copri), a gut commensal, has been reported to be an immune-relevant organism in individuals with rheumatoid arthritis (RA). This study sought to evaluate anti-P copri (anti-Pc) antibody responses in our participant cohorts and to determine when in the natural history of RA such responses develop. METHODS: We analyzed serum levels of immunoglobulin A (IgA) and IgG antibodies from a 27-kd protein of P copri (anti-Pc-p27), an immunogenic P copri protein, in study participants at risk of developing RA, participants who transitioned to RA, participants with early RA (<1 year of disease), and participants with established RA, with comparisons made to their matched controls. We also evaluated anti-Pc-p27 antibody levels in individuals stratified by RA-related autoantibody status. RESULTS: Overall, participants with RA had significantly higher IgA anti-Pc-p27 antibody levels and trended toward higher IgG anti-Pc-p27 antibody levels compared with matched controls. When stratified by early versus established RA, participants with early RA had median IgG anti-Pc-p27 antibody levels that were overall higher, whereas median IgA anti-Pc-p27 antibody levels were statistically significantly higher in participants with established RA compared with their matched controls. In the autoantibody-specific analyses, the at-risk population with anti-cyclic citrullinated peptide (anti-CCP) antibodies, but not rheumatoid factor (RF), trended toward increased levels of IgG anti-Pc-p27. Additionally, RA participants who were seropositive for both CCP and RF had significantly increased levels of IgA anti-Pc-p27 antibodies and trended toward higher levels of IgG anti-Pc-p27 antibodies compared with matched controls. CONCLUSION: Our findings support a potential etiologic role for P copri in both RA preclinical evolution and the subsequent pathogenesis of synovitis.","journal":"Arthritis & Rheumatology","year":2022,"id":242961,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9639,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":368463,"name":"Elizabeth A. Bemis","orcid":"0000-0002-3556-3175","position":1,"is_corresponding":false},{"id":685868,"name":"Kristina Ramsden","orcid":null,"position":2,"is_corresponding":false},{"id":874609,"name":"Cassidy Lowell","orcid":null,"position":3,"is_corresponding":false},{"id":368462,"name":"Kristen J. Polinski","orcid":"0000-0001-9825-6095","position":4,"is_corresponding":false},{"id":335239,"name":"Marie L. Feser","orcid":"0009-0003-0598-853X","position":5,"is_corresponding":false},{"id":495664,"name":"Chelsie Fleischer","orcid":"0000-0001-5706-7618","position":6,"is_corresponding":false},{"id":342496,"name":"M. Kristen Demoruelle","orcid":"0000-0002-2563-5155","position":7,"is_corresponding":false},{"id":226226,"name":"Jane H. Buckner","orcid":"0000-0002-9005-1885","position":8,"is_corresponding":false},{"id":27544,"name":"Peter K. Gregersen","orcid":"0000-0003-1613-1518","position":9,"is_corresponding":false},{"id":368466,"name":"Richard M. Keating","orcid":"0000-0003-1098-5141","position":10,"is_corresponding":false},{"id":314417,"name":"Ted R. Mikuls","orcid":"0000-0002-0897-2272","position":11,"is_corresponding":false},{"id":343503,"name":"James R. O’Dell","orcid":null,"position":12,"is_corresponding":false},{"id":251786,"name":"Michael H. Weisman","orcid":"0000-0001-5568-388X","position":13,"is_corresponding":false},{"id":305659,"name":"Kevin D. Deane","orcid":"0000-0003-2211-4861","position":14,"is_corresponding":false},{"id":230361,"name":"Jill M. Norris","orcid":"0000-0001-8674-2598","position":15,"is_corresponding":false},{"id":311008,"name":"Allen C. Steere","orcid":"0000-0002-5268-9853","position":16,"is_corresponding":false},{"id":41942,"name":"V. Michael Holers","orcid":"0000-0002-5634-7746","position":17,"is_corresponding":false},{"id":226254,"name":"Jennifer Seifert","orcid":"0000-0001-5851-7246","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T00:23:10.218426Z","pmid":"36259174","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}